Pelargonidin Protects Against Renal Injury in a Mouse Model of Sepsis

Journal of Medicinal Food
In-Chul Lee, Jong-Sup Bae

Abstract

Pelargonidin (PEL) is a well-known red pigment found in plants, and it has been reported to have important biological activities that are potentially beneficial for human health. This study was initiated to determine whether PEL could modulate renal functional damage in a mouse model of sepsis, and to elucidate the underlying mechanisms. The potential of PEL treatment to reduce renal damage induced by cecal ligation and puncture (CLP) surgery in mice was measured by assessment of serum creatinine, blood urea nitrogen (BUN), lipid peroxidation, total glutathione, glutathione peroxidase (GSH-Px) activity, catalase activity, and superoxide dismutase (SOD) activity. Treatment with PEL resulted in elevated plasma levels of BUN and creatinine, and of protein in urine in mice with CLP-induced renal damage. Moreover, PEL inhibited nuclear factor-κB activation and reduced the induction of nitric oxide synthase and excessive production of nitric acid. PEL treatment also reduced the plasma levels of interleukin-6 and tumor necrosis factor-α reduced lethality due to CLP-induced sepsis, increased lipid peroxidation, and markedly enhanced the antioxidant defense system by restoring the levels of SOD, GSH-Px, and catalase in kidney tissues. T...Continue Reading

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Citations

Jul 26, 2019·Journal of Toxicology and Environmental Health. Part a·Wonhwa LeeJong-Sup Bae
Aug 14, 2019·International Journal of Environmental Health Research·Wonhwa LeeJong-Sup Bae
Sep 10, 2019·The American Journal of Chinese Medicine·Wonhwa LeeJong-Sup Bae
Jan 26, 2020·Journal of Asian Natural Products Research·In-Chul Lee, Jong-Sup Bae
May 2, 2020·Journal of Cellular Physiology·Kyung-Min KimJong-Sup Bae
Nov 25, 2019·Journal of Natural Medicines·Bong-Seon LeeJong-Sup Bae
Feb 23, 2020·Journal of Asian Natural Products Research·In-Chul Lee, Jong-Sup Bae
Feb 27, 2020·International Journal of Molecular Sciences·Wonhwa LeeJong-Sup Bae
Sep 6, 2020·Antioxidants·Vidmantas BendokasJulius Liobikas
Nov 28, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Wonhwa LeeJong-Sup Bae
Feb 25, 2021·Preparative Biochemistry & Biotechnology·Yuanjing ZhouYousong Zhou
Jan 14, 2022·Journal of Natural Medicines·Soo Ho RyuJong-Sup Bae
Jan 14, 2022·Journal of Asian Natural Products Research·In-Chul Lee, Jong-Sup Bae

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Methods Mentioned

BETA
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