Pellicle formation in the malaria parasite

Journal of Cell Science
Maya KonoTim W Gilberger

Abstract

The intraerythrocytic developmental cycle of Plasmodium falciparum is completed with the release of up to 32 invasive daughter cells, the merozoites, into the blood stream. Before release, the final step of merozoite development is the assembly of the cortical pellicle, a multi-layered membrane structure. This unique apicomplexan feature includes the inner membrane complex (IMC) and the parasite's plasma membrane. A dynamic ring structure, referred to as the basal complex, is part of the IMC and helps to divide organelles and abscises in the maturing daughter cells. Here, we analyze the dynamics of the basal complex of P. falciparum. We report on a novel transmembrane protein of the basal complex termed BTP1, which is specific to the genus Plasmodium. It colocalizes with the known basal complex marker protein MORN1 and shows distinct dynamics as well as localization when compared to other IMC proteins during schizogony. Using a parasite plasma membrane marker cell line, we correlate dynamics of the basal complex with the acquisition of the maternal membrane. We show that plasma membrane invagination and IMC propagation are interlinked during the final steps of cell division.

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Citations

Jun 9, 2020·PLoS Pathogens·Rachel M RudlaffJeffrey D Dvorin
Dec 12, 2019·Frontiers in Cellular and Infection Microbiology·Tansy C Hammarton
Jan 26, 2020·Nature Reviews. Microbiology·Joachim M MatzMichael J Blackman
Jun 26, 2020·Frontiers in Cellular and Infection Microbiology·Marc-Jan GubbelsManoj T Duraisingh
Aug 31, 2017·Scientific Reports·Paul-Christian BurdaVolker T Heussler
May 18, 2019·Nature Communications·Rachel M RudlaffJeffrey D Dvorin
Jan 26, 2021·Frontiers in Cellular and Infection Microbiology·Josie Liane FerreiraTim-Wolf Gilberger
Apr 30, 2021·Frontiers in Cellular and Infection Microbiology·Marc-Jan GubbelsKlemens Engelberg

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Methods Mentioned

BETA
PCR
transfection
transgenic

Software Mentioned

Just another Colocalization Plugin ( JACoP )
Excel
ImageJ
Imaris

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