Pellino enhances innate immunity in Drosophila

Mechanisms of Development
Amirhossein HaghayeghiFrieder Schöck

Abstract

The innate immune response is a defense mechanism against infectious agents in both vertebrates and invertebrates, and is in part mediated by the Toll pathway. Toll receptor activation upon exposure to bacteria causes stimulation of Pelle/IRAK kinase, eventually resulting in translocation of the transcription factor NF-kappaB to the nucleus. Here we show that Pellino, a highly conserved protein interacting with activated Pelle/IRAK, acts as a positive regulator of innate immunity in Drosophila.

References

May 20, 1999·Mechanisms of Development·J GrosshansC Nüsslein-Volhard
Dec 18, 2001·Nature Immunology·Servane Tauszig-DelamasureJean-Luc Imler
Jul 27, 2002·Developmental Biology·Frieder Schöck, Norbert Perrimon
Oct 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kang-Yeol YuMaureen A Harrington
Feb 1, 2003·Mechanisms of Development·Iphigenie CharatsiBernard Moussian
Mar 12, 2003·Genes & Development·Frieder Schöck, Norbert Perrimon
Apr 15, 2003·Nature Immunology·François LeulierBruno Lemaitre
Jul 23, 2003·Bioinformatics·Perikles Simon
Sep 10, 2003·Proceedings of the National Academy of Sciences of the United States of America·R Grace ZhaiHugo J Bellen
Mar 31, 2005·Trends in Immunology·Takahiro Tanji, Y Tony Ip
Dec 1, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jason G HomsyDirk Bohmann
Jan 5, 2007·Annual Review of Immunology·Bruno Lemaitre, Jules Hoffmann
Jul 20, 2007·Journal of Cellular and Molecular Medicine·Reinout SchauvliegeRudi Beyaert
Jan 2, 2008·The Journal of Cell Biology·Klodiana Jani, Frieder Schöck
Mar 11, 2008·The Journal of Biological Chemistry·Hui XiaoXiaoxia Li
Oct 16, 2008·Developmental Cell·Huaping TangCarl Hashimoto
Jun 6, 2009·Annual Review of Biochemistry·Brian SkaugZhijian J Chen
Dec 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jitendra S KanodiaStanislav Y Shvartsman

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Citations

Jun 5, 2013·Developmental and Comparative Immunology·Chris G C Jacobs, Maurijn van der Zee
Jul 13, 2013·The Journal of Biological Chemistry·Alban OrdureauPhilip Cohen
Jun 23, 2012·Open Biology·Ilias Kounatidis, Petros Ligoxygakis
Jan 28, 2014·Developmental and Comparative Immunology·Chaozheng LiXiaopeng Xu
Feb 3, 2011·European Journal of Immunology·Bryan D GriffinPaul N Moynagh
Feb 13, 2013·Insect Molecular Biology·J AbrudanM A McDowell
Jun 19, 2015·Immunological Reviews·Fiachra Humphries, Paul N Moynagh
Sep 21, 2011·Developmental and Comparative Immunology·Susanna ValanneMika Rämet
Jan 22, 2014·Nature Reviews. Immunology·Paul N Moynagh
Aug 21, 2012·The Journal of Biological Chemistry·Karine EnesaPhilip Cohen
Oct 3, 2018·Neuromolecular Medicine·Anat ShmueliGalit Shohat-Ophir
Jan 7, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susanna ValanneMika Rämet
Jul 23, 2021·BMC Genomics·Letícia Ferreira LimaRenata Schama

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