PELOD-2: an update of the PEdiatric logistic organ dysfunction score

Critical Care Medicine
Stéphane LeteurtreGroupe Francophone de Réanimation et d’Urgences Pédiatriques (GFRUP)

Abstract

Multiple organ dysfunction syndrome is the main cause of death in adult ICUs and in PICUs. The PEdiatric Logistic Organ Dysfunction score developed in 1999 was primarily designed to describe the severity of organ dysfunction. This study was undertaken to update and improve the PEdiatric Logistic Organ Dysfunction score, using a larger and more recent dataset. Prospective multicenter cohort study. Nine multidisciplinary, tertiary-care PICUs of university-affiliated hospitals in France and Belgium. All consecutive children admitted to these PICUs (June 2006-October 2007). None. We collected data on variables considered for the PEdiatric Logistic Organ Dysfunction-2 score during PICU stay up to eight time points: days 1, 2, 5, 8, 12, 16, and 18, plus PICU discharge. For each variable considered for the PEdiatric Logistic Organ Dysfunction-2 score, the most abnormal value observed during time points was collected. The outcome was vital status at PICU discharge. Identification of the best variable cutoffs was performed using bivariate analyses. The PEdiatric Logistic Organ Dysfunction-2 score was developed by multivariable logistic regressions and bootstrap process. We used areas under the receiver-operating characteristic curve to ...Continue Reading

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