Pelvic adhesions contain sex steroid receptors and produce angiogenesis growth factors

Fertility and Sterility
H P WiczykM T Reece

Abstract

To evaluate female pelvic adhesion tissue for the presence of estrogen receptor (ER), progesterone receptor (PR), basic fibroblastic growth factor (basic-FGF), and vascular endothelial growth factor (VEGF). Descriptive study. Patients at a tertiary medical center. Female reproductive age patients undergoing gynecologic surgery who were not receiving hormonal therapy. Female reproductive tract peritoneal adhesion tissue was excised, frozen, and sent for immunohistologic evaluation. Presence of ER, PR, basic-FGF, and VEGF in adhesion tissue. Nineteen of 19 specimens were positive for PR; 16 of 19 specimens were positive for ER, which was present in a variety of the different cell types constituting adhesion. Vascular endothelial growth factor and basic-FGF were detected in endothelial cells of blood vessels supplying this tissue as well as in mesothelial cells. Adhesion tissue contains ER, PR, and growth factors that may be important in the genesis of the permanent fibrovascular bands between pelvic organs. This supports the theoretical possibility of hormonal manipulation of these tissues to negatively influence postoperative pelvic adhesion formation.

References

Jul 1, 1989·The Journal of Surgical Research·M FukasawaG S DiZerega
Apr 1, 1986·American Journal of Obstetrics and Gynecology·J A HillO E Talledo
Sep 1, 1973·American Journal of Surgery·M A Weibel, G Majno
Sep 1, 1995·Obstetrical & Gynecological Survey·J D GordonR B Jaffe
Aug 1, 1996·Seminars in Reproductive Endocrinology·E Oral, A Arici
Mar 1, 1995·Human Reproduction Update·S K Smith

❮ Previous
Next ❯

Citations

Mar 17, 2010·Archives of Gynecology and Obstetrics·Atsushi ImaiNoriko Suzuki
Nov 11, 2006·Diseases of the Colon and Rectum·Jonathan C EpsteinSarah E Herrick
Mar 24, 2004·Fertility and Sterility·Carlos Roger MolinasPhilippe Robert Koninckx
Dec 4, 2009·Human Reproduction·Xinmei ZhangCaiyun Zhou
Jul 29, 2008·Current Opinion in Obstetrics & Gynecology·Mostafa MetwallyTin Chiu Li
Jan 12, 2005·Reproductive Biology and Endocrinology : RB&E·Ujjwal K RoutMichael P Diamond
Aug 30, 2008·World Journal of Gastroenterology : WJG·Ronan A Cahill, H Paul Redmond
Dec 16, 2011·World Journal of Gastroenterology : WJG·Hussein M Atta
Aug 16, 2015·Surgical Endoscopy·Denise M D Özdemir-van BrunschotMichiel C Warlé
Feb 12, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Huseyin Levent KeskinAyse Filiz Avsar
Apr 1, 2008·The Journal of Surgical Research·Sendia KimMark Puder
Oct 4, 2011·International Journal of Surgery·Allison H MaciverA M James Shapiro
Feb 12, 2005·Fertility and Sterility·Michael P DiamondGhassan Saed
Feb 7, 2006·The Journal of Surgical Research·Genevieve M Boland, Ronald J Weigel
Nov 2, 2005·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·K ThalerSusan R Abramson
Apr 25, 2007·Human Reproduction Update·C NappiG Bifulco
Jan 1, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·A E Schindler
Oct 22, 2009·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Serdar BozkurtIlhami Taner Kale
Mar 20, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Noriko SuzukiAtsushi Imai
Jul 9, 2008·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Michael StarkGian Carlo di Renzo
Feb 24, 2001·Clinical Orthopaedics and Related Research·N FukuiK Nakamura
Apr 18, 2003·The European Journal of Surgery = Acta Chirurgica·Julian W MallChristian Pollmann
Nov 21, 2013·Experimental and Therapeutic Medicine·Fengfeng LiCunyi Fan
Aug 28, 2021·Biomedicines·Ali Fatehi HassanabadPaul W M Fedak

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.