Pelvic lymphadenectomy as alternative to postoperative radiotherapy in high risk early stage endometrial cancer

Archives of Gynecology and Obstetrics
A PapanikolaouG Makedos

Abstract

The purpose of the study is to evaluate whether surgery followed by radiotherapy in high-risk patients of early stage endometrial cancer can be replaced by formal surgical staging. Cancer-related survival and recurrence-free survival (RFS) were the endpoints of the analysis. One hundred and eighteen patients with endometrioid endometrial adenocarcinoma between 1996-2003 were reviewed. Patients with incomplete follow-up and extrauterine spread excluded, leaving 78 women in the final analysis. Low-risk patients (n=37) (Grade 1, myometrial infiltration <1/2 or Grade 2, <1/3), treated by standard surgical procedure including total abdominal hysterectomy, bilateral salpingo-oophorectomy and peritoneal washing, while staging lymphadenectomy (n=24) or postoperative irradiation (n=17) was added in the high-risk group (Grade 1, >1/2 or Grade 2, >1/3 or Grade 3). The median age of patients was 65 years (range, 35-80 years) and the median follow-up 38 months (range, 9-98 months). The recurrence rate in low-risk patients was 2.7%, the cancer-related survival 97.5% and RFS 97%, while in the high-risk patients 12%, 93% and 88%, respectively. Comparing the therapeutic modalities (staging lymphadenectomy vs. postoperative irradiation) in the h...Continue Reading

References

Nov 1, 1992·American Journal of Obstetrics and Gynecology·H D HomesleyS S Lentz
May 1, 1992·Gynecologic Oncology·A H WolfsonS G Hilsenbeck
May 1, 1990·International Journal of Radiation Oncology, Biology, Physics·R A Potish, K E Dusenbery
Apr 15, 1985·American Journal of Obstetrics and Gynecology·P J DiSaiaJ A Blessing
Mar 1, 1993·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·D ChassagneG Michel
Feb 1, 1996·Gynecologic Oncology·H G Ball
Sep 1, 1996·Obstetrics and Gynecology·D M LarsonK K Johnson
Apr 1, 1997·American Journal of Obstetrics and Gynecology·J W OrrP F Orr
Mar 10, 1998·Obstetrics and Gynecology·D M LarsonB R Krawisz
Jan 15, 1999·Gynecologic Oncology·E L TrimbleR C Park
Mar 10, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G GattaA Verdecchia
Feb 19, 2000·Hematology/oncology Clinics of North America·H B MussS M Lichtman
Dec 17, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·K W K LoT K H Chung
Apr 22, 2004·Gynecologic Oncology·Christine GoudgePeter Morris
Feb 22, 2005·Gynecologic Oncology·Andrea MarianiKarl C Podratz
Mar 2, 2005·Obstetrics and Gynecology·Inbar Ben-ShacharJeffrey M Fowler
Mar 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Janiel M CragunAndrew Berchuck
Mar 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carien L Creutzberg
Aug 9, 2005·Lancet·Frederic AmantIgnace Vergote

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Citations

May 4, 2011·Archives of Gynecology and Obstetrics·Ioannis Mylonas, Christian Schindlbeck
Nov 28, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Roberto AngioliPierluigi Benedetti-Panici
Nov 27, 2008·Journal of the National Cancer Institute·Pierluigi Benedetti PaniciCostantino Mangioni
Jun 10, 2010·Current Opinion in Oncology·Yann Delpech, Emmanuel Barranger
Sep 27, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Roberto AngioliFrancesco Plotti
Jul 16, 2014·Archives of Gynecology and Obstetrics·Ioannis KalogiannidisTheodoros Agorastos
Aug 31, 2011·Revista da Associação Médica Brasileira·Antonio Carlos ZulianiGustavo Antonio de Souza
Mar 29, 2011·Histopathology·Kitty PavlakisZannis Voulgaris
Nov 29, 2016·Expert Review of Anticancer Therapy·Stella CapriglioneRoberto Angioli
Mar 22, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Pluvio J CoronadoMiguel A Herraiz
May 2, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·F H van WijkH C van Doorn
Dec 31, 2017·Journal of the Chinese Medical Association : JCMA·Taner TuranDerman Basaran
Dec 4, 2019·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Cem OnalFerah Yildiz
Jul 28, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Jing LiuMayinuer Niyazi

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