PMID: 8591082Nov 1, 1995Paper

Pelvic neuroblastoma--implications for a new favorable subgroup: a Children's Cancer Group experience

Annals of Surgical Oncology
G M HaaseK K Matthay

Abstract

The survival in neuroblastoma is influenced by patient age, disease stage, tumor site, and several biologic factors. This study was undertaken to determine if primary pelvic lesions are associated with an unusually favorable outcome. Nine hundred eighty-six patients registered on Children's Cancer Group studies from 1980 to 1993 were reviewed, and 41 (4.3%) were found to have pelvic tumors. Survival was analyzed, and correlations among age, stage of disease, surgical resectability, histopathology, serum ferritin, and N-myc oncogene amplification were evaluated. Age at diagnosis was comparable between patients with pelvic and nonpelvic tumors. Disease distribution was similar, with stages III and IV comprising 78% (32 of 41) of pelvic lesions compared with 73% (692 of 945) for nonpelvic tumors. There was no outcome difference in favorable stages (I, II, and IV-S), with 3-year progression-free survival rates of 88% and 82% for pelvic and nonpelvic sites, respectively. However, in stages III and IV, the 3-year progression-free survival was 70% for pelvic lesions compared with 47% for nonpelvic tumors (p = 0.04). Some favorable biologic factors were more common in children with pelvic lesions. The pelvis is an unusual primary site ...Continue Reading

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Citations

May 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marc-David LeclairHerve Rubie
Apr 2, 2013·Pediatric Surgery International·Shin-ichiro KojimaKen Tanikawa
Sep 21, 2013·Pediatric Hematology and Oncology·Jason R WooGeorge Chiang
Oct 15, 2005·Pediatric Annals·Ellen Benya
Apr 21, 2017·Oncotarget·Xiangdong TianQiang Zhao
Aug 31, 2020·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·Alexandra Froeba-PohlJochen Hubertus
Jul 29, 2000·Pediatric Hematology and Oncology·B BrichardF Wese
Aug 17, 2006·Journal of Pediatric Hematology/oncology·Antonio D'AlessioRoberto Luksch
Aug 27, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kieuhoa T VoSteven G DuBois
Nov 1, 2012·Journal of Child Neurology·Cristina L MartinsMaria José Fonseca
Jun 25, 2005·Archives of Pathology & Laboratory Medicine·Stephen J QualmanUNKNOWN Cancer Committee, College of American Pathologists

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