Pemetrexed-induced cellulitis: a rare toxicity in non-small cell lung cancer treatment

Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners
Stamatis KatsenosChara Panagou

Abstract

Pemetrexed is indicated for locally advanced or metastatic non-squamous non-small-cell lung cancer as an initial treatment in combination with cisplatin or after prior chemotherapy as a single agent. It is generally a well-tolerated drug. The most common adverse reactions (incidence ≥ 20%) with single-agent use are fatigue, nausea, and anorexia. Additional common side effects when used in combination with cisplatin include vomiting, neutropenia, leukopenia, anemia, stomatitis/pharyngitis, thrombocytopenia, and constipation. Peripheral edema with associated erythema has rarely been described as an adverse effect. Herein, we report a patient with advanced non-small-cell lung cancer who experienced bilateral peripheral edema after pemetrexed administration. Discontinuation of pemetrexed and corticosteroids use completely resolved peripheral edema.

References

Oct 28, 2008·Japanese Journal of Clinical Oncology·Jong-Mu SunJong Seok Lee
Feb 15, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Sandra P D'AngeloChristopher G Azzoli
Sep 6, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Belen EguiaJacques Cadranel

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Citations

Mar 3, 2015·Medicina clínica·María Castellanos-González, Javier Ballesteros Bargues
Jun 10, 2014·Ophthalmic Plastic and Reconstructive Surgery·Neeraj ManglaEdward J Wladis
Aug 9, 2020·Annales de dermatologie et de vénéréologie·M SarrazinD Staumont-Sallé

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