Abstract
Pemphigus is a rare autoimmune blistering disease, reported to be associated with other coexisting and autoimmune diseases, including thyroid diseases, rheumatoid arthritis, alopecia areata, vitiligo, systemic lupus erythematosus, scleroderma and rare entities such as myasthenia gravis. To identify and describe patients with pemphigus with a diagnosed comorbidity, and to quantify the risk of additional comorbidities. This was a cross-sectional study of patients with pemphigus treated at a tertiary referral centre. Prevalence rates of 15 comorbid diseases were calculated. Age-standardized prevalence ratio (SPR) and 95% CI were calculated in comparison with prevalence rates in the general Canadian population using data from the Canadian Community Health Survey. Data were analysed using SAS software. In total, 295 patients were identified. An increased risk of hypothyroidism (n = 38, SPR = 1.53, 95% CI 1.08-2.10) and inflammatory bowel disease (IBD) (SPR = 1.48, 95% CI 0.40-3.80), and a two-fold increased risk of diabetes (SPR = 2.20, 95% CI 1.64-2.87) were observed. Patients with pemphigus have a higher incidence of hypothyroidism, IBD and diabetes compared with the general population. As part of pemphigus investigations and surv...Continue Reading
References
Feb 1, 1990·American Journal of Epidemiology·K Ulm
Sep 1, 1974·Oral Surgery, Oral Medicine, and Oral Pathology·S PisantiL N Posner
Aug 1, 1980·Journal of the American Academy of Dermatology·J P Callen
Sep 1, 1994·Journal of the American Academy of Dermatology·A FiroozA R Ahmed
Dec 6, 2000·The Australasian Journal of Dermatology·C S OngS Lee
Sep 27, 2003·Dermatologic Therapy·S W YehA Razzaque Ahmed
Oct 29, 2005·American Journal of Clinical Dermatology·Shih Wei YehRazzaque A Ahmed
Feb 16, 2006·Epidemiology·Emily C SomersAndrew J Hall
Apr 20, 2007·International Journal of Dermatology·Evangelia Z MichailidouDemetrios Z Antoniades
Mar 25, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·A AnsarM Farshchian
Feb 2, 2010·Journal of the American Academy of Dermatology·Maryam DaneshpazhoohCheyda Chams-Davatchi
Feb 3, 2011·Journal of Korean Medical Science·Seo Yun KimJae-Joon Yim
Jun 18, 2011·Clinics in Dermatology·Pascal Joly, Noémie Litrowski
Jun 28, 2011·International Journal of Dermatology·Yael A LeshemDaniel Mimouni
Dec 6, 2011·Clinics in Dermatology·Suzana Ljubojevic, Jasna Lipozenčić
May 9, 2012·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Marcello M S NicoSilvia V Lourenço
Sep 22, 2012·International Journal of Dermatology·Afsaneh AlaviNeil H Shear
Nov 3, 2012·TheScientificWorldJournal·Mukaddes KavalaBurce Can
Jun 29, 2013·Clinics in Dermatology·Eleonora RuoccoAda Lo Schiavo
Citations
Sep 20, 2015·The British Journal of Dermatology·D HsuJ I Silverberg
Feb 13, 2016·The British Journal of Dermatology·D Y HsuJ I Silverberg
Mar 13, 2016·Dermatologic Therapy·Yi-Xiu BaiHong-Duo Chen
Feb 1, 2018·Oral Diseases·Y HassonaF Sawair
Mar 1, 2017·The British Journal of Dermatology·T Hashimoto
Sep 22, 2018·Drugs·Kyle T AmberMichael Hertl
Aug 30, 2018·Frontiers in Medicine·Dan VodoEli Sprecher
Feb 9, 2020·Archives of Dermatological Research·Khalaf KridinArnon D Cohen
Oct 20, 2018·Immunologic Research·Khalaf KridinArnon D Cohen
Jun 28, 2018·Reviews in Endocrine & Metabolic Disorders·Enke BaldiniSalvatore Ulisse
Nov 17, 2016·Journal of Diabetes Research·José González-SerranoGonzalo Hernández
Feb 22, 2017·International Journal of Dermatology·Zhen Yu Crystal PhuanHong Liang Tey
Apr 11, 2020·The Journal of Allergy and Clinical Immunology·Shohei EgamiMasayuki Amagai
Jul 24, 2021·Clinical Case Reports·Fatemeh MohagheghMina Rezaei
Oct 12, 2021·Experimental and Therapeutic Medicine·Victor-Vlad CostanMihaela Paula Toader
Nov 4, 2021·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Federico BardazziAmbra Di Altobrando
Nov 24, 2021·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Federico BardazziAmbra Di Altobrando