Pemphigus herpetiformis in South Tunisia: a clinical expression of pemphigus foliaceus?

International Journal of Dermatology
Ameni JerbiH Masmoudi

Abstract

Pemphigus herpetiformis (PH) is a rare subtype of pemphigus combining clinical features of dermatitis herpetiformis and the immunopathologic characteristics of pemphigus. We aimed to analyze the epidemiological, clinical, and immunological presentation and management of the disease in a cohort of south Tunisian patients with a long-term follow-up. We included all patients with confirmed PH followed from January 1987 to December 2015 in the dermatology department. We included 24 south Tunisian female patients with a mean age of 36 years (20-63), mainly from rural origin (84%). All patients had exclusive skin lesions. Clinical features combined erythematous, vesicular, or bullous lesions, with circinate borders mainly on the trunk and limbs associated with severe pruritus (91%). Peripheral hypereosinophilia was noted in 31% of cases. Histological examination demonstrated no intraepithelial (50%), suprabasal (35%), or subcorneal cleavage (15%). Eosinophilic spongiosis was seen in 42% of cases. On direct immunofluorescence, there was an intercellular staining in 96% of cases composed mainly of IgG and C3 (79%). Indirect immunofluorescence was positive in 71% of cases. Reactivity was mainly directed against Dsg1. Dapsone alone was i...Continue Reading

References

Jun 1, 1975·International Journal of Dermatology·S JablonskaJ Chorzelska
Nov 1, 1987·International Journal of Dermatology·E MaciejowskaT Chorzelski
Jun 1, 1973·Archives of Dermatology·F J DeMento, R W Grover
Jul 1, 1973·The British Journal of Dermatology·P P SeahM Feiwel
Apr 29, 1998·International Journal of Dermatology·G MicaliM R Nasca
Feb 18, 1999·The Journal of Clinical Investigation·M G MahoneyJ R Stanley
May 13, 1999·Journal of the American Academy of Dermatology·N D RobinsonL S Chan
Aug 24, 1999·Archives of Dermatology·K IshiiT Hashimoto
Feb 1, 2002·American Journal of Epidemiology·Sylvie Bastuji-GarinMohamed R Kamoun
Oct 4, 2002·Acta Dermato-venereologica·Giovanni Maria Palleschi, Barbara Giomi
Jan 11, 2003·Journal of the American Academy of Dermatology·A KozlowskaS Jablonska
May 21, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·O AbidaUNKNOWN Franco-Tunisian Group of Survey and Research on Pemphigus
Jun 3, 2009·The British Journal of Dermatology·O AbidaUNKNOWN Franco-Tunisian Group for Survey and Research on Pemphigus
Aug 14, 2009·The British Journal of Dermatology·O AbidaH Turki
Jan 6, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·T MiuraT Yamamoto
Mar 6, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·D MimouniM David
May 29, 2010·The Journal of Dermatology·Hiroko NakashimaKunihiko Tamaki
Jun 15, 2010·Journal of the American Academy of Dermatology·Chiharu TateishiTakashi Hashimoto
Sep 3, 2010·Pediatric Dermatology·Isabela B DuarteAdauto J F Nunes
Dec 6, 2011·Clinics in Dermatology·Michael KasperkiewiczDetlef Zillikens
Dec 8, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·A KhaledB Fazaa
Jan 1, 2011·ISRN Pediatrics·O HocarS Amal
Oct 31, 2013·Actas dermo-sifiliográficas·P Fuentes-FinkelsteinL Puig
Jan 30, 2014·Journal of the American Academy of Dermatology·Michael KasperkiewiczStefania Jabłońska
Oct 8, 2014·Annales de dermatologie et de vénéréologie·W SaidiR Nouira
Jan 21, 2015·International Journal of Dermatology·Philip M LawsNeil H Shear
Nov 5, 2016·Actas dermo-sifiliográficas·J I Galvañ-Pérez Del PulgarM Linares-Barrios
Oct 17, 2016·Actas dermo-sifiliográficas·V L TaliercioM Larralde

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Citations

Jul 25, 2019·International Journal of Dermatology·Ameni JerbiHatem Masmoudi

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