Pemphigus in South Africa

International Journal of Dermatology
J AboobakerM G Hammond

Abstract

Pemphigus is an autoimmune disease characterized by intraepidermal blistering. We describe the demography, prevalence, clinical features, response to treatment, and human leukocyte antigen (HLA) characteristics of pemphigus in Kwa-Zulu Natal, South Africa. All patients with pemphigus were prospectively recruited over 12 years from January 1987 to December 1999. The demography, clinical features, histology, and immunofluorescence (IF) were recorded. In a subset of patients, HLA tests were performed. One hundred and twelve patients had pemphigus. Pemphigus foliaceus (PF) was the commonest variant seen (62 patients) and 80% of these patients were black. The mean age was 43 years (12-93 years) and the male to female ratio was 1 : 1.4. Fifty patients had pemphigus vulgaris (PV), of whom 82% were Indian. The mean age of presentation of PV was 48 years (21-82 years). The male to female ratio was 1 : 1.7. There was no mucosal involvement in PF. PV patients had painful oral lesions. The mortality rate was 14% in the total sample (six in PV and two in PF). HLA-B8 was positive in 41% of patients with PF (P < 0.001). PF occurs more commonly in black people, while most cases in Indians present with the PV subtype. Pemphigus patients present...Continue Reading

References

Sep 1, 1979·Lancet·M S ParkJ L Tiwari
Jul 1, 1976·Archives of Dermatology·F R RosenbergC T Nelson
Jan 1, 1992·International Journal of Dermatology·B A Adam
Jan 1, 1989·The Australasian Journal of Dermatology·K KyriakisJ Stratigos
Apr 1, 1989·Journal of the American Academy of Dermatology·L A DiazC Lavrado
Jun 1, 1988·Journal of the American Academy of Dermatology·N Korman
Jul 1, 1988·The British Journal of Dermatology·J S PasrichaU K Khan
Oct 1, 1985·American Journal of Epidemiology·S GrahamD West
Sep 1, 1974·Oral Surgery, Oral Medicine, and Oral Pathology·S PisantiL N Posner
Jul 1, 1965·Dermatologia Internationalis·H C Padilla
Sep 1, 1980·Archives of Dermatology·D G SimonR Zarbo
Jan 1, 1994·Dermatology : International Journal for Clinical and Investigative Dermatology·C WilsonJ S Pasricha
Jan 1, 1993·Archives of Dermatology·J P MoriniJ Revuz
Jan 1, 1996·The British Journal of Dermatology·A MahéP Bobin
Aug 1, 1997·The Journal of Investigative Dermatology. Symposium Proceedings·S A Grando
Jun 16, 1999·International Journal of Dermatology·Q A AlsalehR Dvorak
Jan 1, 1965·Archives of Dermatology·H O PERRY, L A BRUNSTING

❮ Previous
Next ❯

Citations

May 5, 2005·Journal of Autoimmunity·François TronMourad Ben Ayed
Oct 19, 2012·Indian Journal of Dermatology, Venereology and Leprology·Hamideh H QadimAkbar Hasani
Feb 9, 2012·Cutaneous and Ocular Toxicology·Kübra Bozdag, İlgül Bilgin
Nov 15, 2006·Autoimmunity·Sarah E Dick, Victoria P Werth
Apr 20, 2007·International Journal of Dermatology·Evangelia Z MichailidouDemetrios Z Antoniades
Mar 8, 2013·Asian Journal of Psychiatry·Vineet KumarSanjeev Handa
Nov 10, 2009·Autoimmunity Reviews·N Meyer, L Misery
Oct 7, 2015·Cytokine·Soheil Tavakolpour, Vahid Tavakolpour
Sep 2, 2005·International Journal of Dermatology·Zoran GolusinNovak Rajiç
Jun 9, 2005·International Journal of Dermatology·Cheyda Chams-DavatchiZahra Naraghi
Jul 2, 2009·The British Journal of Dermatology·G MarazzaUNKNOWN Autoimmune bullous disease Swiss study group
Apr 11, 2006·Skinmed·Ali AsilianGita Faghini
Nov 9, 2007·International Journal of Dermatology·Nafiseh EsmailiSiavash Toosi
May 17, 2006·International Journal of Dermatology·Soner UzunErkan Alpsoy
Dec 21, 2011·International Journal of Dermatology·Maryam DaneshpazhoohZahra Safai-Naraghi
May 17, 2013·International Journal of Dermatology·Nadège CordelBenoît Tressières
Feb 18, 2012·Oral Diseases·N CirilloS A Grando
Oct 31, 2009·Clinical and Experimental Dermatology·F ShaikA Mosam
Dec 21, 2013·The Journal of Dermatology·Xiaoling ZhuShuyun Zheng
Jan 16, 2015·Archives of Dermatological Research·Erkan AlpsoySoner Uzun
Jul 5, 2005·Lancet·Jean-Claude Bystryn, Jennifer L Rudolph
Jan 24, 2007·Journal of Cutaneous Medicine and Surgery·Amrinder J KanwarTarun Narang
Apr 4, 2017·The British Journal of Dermatology·N C DlovaA Mosam
Sep 1, 2018·International Journal of Dermatology·Pamela N MaduKarolyn A Wanat
Sep 20, 2018·The British Journal of Dermatology·S Y ZhangW Li
Jun 26, 2015·Journal of Sports Sciences·Irene R FaberMaria W G Nijhuis-Van der Sanden
Jul 14, 2021·PloS One·Omayma SiddigAhmed M Suleiman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.