Pemphigus vegetans of the oral cavity

International Journal of Dermatology
Anastasios K MarkopoulosThomas Zaraboukas

Abstract

Pemphigus vegetans, a variant of pemphigus vulgaris, constitutes a rare form of all pemphigus cases, and oral involvement is common. Two clinical subtypes of pemphigus vegetans exist, characterized initially by flaccid bullae and erosions (Neumann) or pustules (Hallopeau). Both subtypes subsequently develop into hyperpigmented vegetative plaques with pustules and hypertrophic granulation tissue at the periphery. We report three cases of pemphigus vegetans with oral manifestations exclusively. Two patients were male aged 30 and 45 years old, respectively, while one was a 51-year-old female. Oral lesions in all cases consisted of erosions and whitish, vegetating plaques. The histopathological characteristics were in all cases identical. The spinous cell layer was characterized by intense acanthosis and by the presence of vesicles between the spinous and basal cell layers. Inside the vesicles exudative elements were observed consisting mainly of eosinophils. In the upper lamina propria severe inflammatory reaction was observed. Streptavidin-biotin immunoperoxidase technique showed in all cases intercellular epithelial deposition of IgG and C3.

References

Aug 1, 1992·Journal of the American Academy of Dermatology·G M PintoT Vale
Sep 1, 1992·The British Journal of Dermatology·J H Sillevis SmittJ C Van Nierop
Jan 1, 1983·Dermatologica·F S Larsen, J Clausen
Mar 1, 1984·International Journal of Dermatology·A R Ahmed, D A Blose
Nov 12, 1998·Journal of the American Academy of Dermatology·J B DownieS R Cohen
Jan 23, 1999·Clinical and Experimental Dermatology·M IchimiyaM Muto
Apr 2, 1999·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·M L SorianoL Requena
Jun 29, 2001·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·T JansenG Plewig

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Citations

Nov 29, 2012·Indian Dermatology Online Journal·Ashish DhamijaRaj K Kothiwala
Nov 26, 2010·Otolaryngologic Clinics of North America·Sherif Said, Loren Golitz
Apr 27, 2010·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Paul C EdwardsNeil Norton
Jul 17, 2008·Oral Diseases·A AkmanE Alpsoy
Jan 5, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·I ZaraaA B Osman
Feb 19, 2013·International Journal of Dermatology·Zoe ApallaDemetrios Ioannides
Mar 1, 2011·The Journal of Dermatology·Jin WeiHong-Duo Chen
Aug 21, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Shalini R GuptaRohan Sethi
Mar 13, 2014·La Presse médicale·Noama DahbiBadia Belaabidia
Feb 22, 2012·Annals of Dermatology·Young-Min SonJong-Rok Lee
Oct 2, 2019·The Australasian Journal of Dermatology·Harsharon KaurChris Lixian Tan
Jan 27, 2012·Ear, Nose, & Throat Journal·Geoffrey A Sigmund, Randy Oppenheimer
Jan 28, 2012·Anais Brasileiros De Dermatologia·André Ricardo AdrianoGabriella Di Giunta

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