PMID: 9438202Jan 23, 1998Paper

Pemphigus vulgaris autoantibody response is linked to HLA-DQB1*0503 in Pakistani patients

Human Immunology
J C DelgadoE J Yunis

Abstract

Pemphigus vulgaris (PV) is an autoimmune disease of the skin and mucous membranes characterized by an autoantibody response against an epidermal cadherin. We performed high resolution HLA class II typing in 19 patients with PV from Rawalpindi, Pakistan and 19 non-Jewish European PV patients from Boston by sequence-specific oligonucleotide probe hybridization. The results were compared with two separate ethnically matched control populations. WE found that PV patients from Pakistan had significantly increased frequencies of DRB1*1404 (p = 0.01), DQA1*0101 (p = 0.02), and DQB1*0503 (p = 0.01). Among the patients of non-Jewish European ancestry, DRB1*1401 (p < 10(-6)), DQA1*0101 (p < 10(-5)) and DQB1*0503 (p < 10(-6)), were increased in PV patients. Formal linkage analysis between the major histocompatibility complex and the PV antibody was performed in 67 relatives of the 19 Pakistani patients. The results showed strong evidence for linkage of HLA-DRB1*1404, DQA1*0101, DQB1*0503, with the presence of PV antibody in relatives' families with a significant logarithm of the odds score of 6.06. Based on the three dimensional structure of class II molecules, we propose that HLA-DQA1*0101 and DQB1*0503, encode a negatively charged P9 pe...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A R AhmedE J Yunis
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A R AhmedC A Alper
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S J ScharfH A Erlich
Jun 1, 1988·Journal of the American Academy of Dermatology·N Korman
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Dec 1, 1986·Pediatrics·P MerlobS H Reisner
Dec 1, 1986·Pediatric Dermatology·J M HupM C de Jong
May 1, 1995·The Journal of Experimental Medicine·J HammerF Sinigaglia
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·K BholA R Ahmed
Jan 1, 1995·The Journal of Experimental Medicine·J R Stanley

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Citations

Sep 10, 2008·Journal of Clinical Immunology·Sheida ShamsBehrouz Nikbin
May 5, 2005·Journal of Autoimmunity·François TronMourad Ben Ayed
Jun 1, 2008·Gut and Liver·Sung-Hoon MoonDo Hyun Park
Sep 23, 2014·Journal of Dermatological Science·Elias OroujiPouran Layegh
Apr 5, 2013·International Journal of Immunogenetics·Z PárnickáM Buc
Jan 16, 2015·Archives of Dermatological Research·Erkan AlpsoySoner Uzun
Nov 27, 2007·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·C BrickM Essakalli
Oct 24, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Crispian Scully, Stephen J Challacombe
Feb 16, 2017·International Journal of Dermatology·Julio M GilIvan D Miziara
Feb 13, 2009·Transfusion·Lin-Yen WangMarie Lin
May 13, 2005·Oral Diseases·M BlackC Scully
Nov 15, 2006·Autoimmunity·François TronSondès Makni
Apr 13, 2010·Autoimmunity·Jan J G M VerschuurenNils Erik Gilhus
May 9, 2012·The British Journal of Dermatology·L YanK Zeng
Jan 3, 2013·International Journal of Dermatology·Cilem Kaya KocOlcay Yegin
May 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Irini A Doytchinova, Darren R Flower
Jun 1, 2015·Molecular Informatics·Ivan Dimitrov, Irini Doytchinova
Aug 30, 2018·Frontiers in Medicine·Dan VodoEli Sprecher
Feb 1, 2016·Primary Dental Journal·Emma Hayes, Stephen J Challacombe
Mar 28, 2018·Indian Journal of Dermatology, Venereology and Leprology·Anuradha PriyadarshiniVisalakshi Jayaseelan
Nov 26, 2010·Otolaryngologic Clinics of North America·Sherif Said, Loren Golitz

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