PMID: 7047173Jan 1, 1982Paper

Penbutolol (Hoe 893d) in primary hypertension. Blood pressure effects, tolerance and plasma concentrations

European Journal of Clinical Pharmacology
K P OhmanB Liander


Penbutolol (Hoe 893d), a long-acting non-selective beta-adrenoceptor blocking agent, was given once daily to 23 patients with primary hypertension, WHO Stages I-II. The dose (50-100mg) needed to achieve the therapeutic goal, i.e. supine diastolic BP less than 95 mm Hg, was titrated individually. On a daily dose of penbutolol 83 +/- 19 mg (mean +/- SD) blood pressure (BP, mean +/- SD) fell from 180 +/- 21/112 +/- 8 mmHg on placebo to 154 +/- 25/94 +/- 14 mmHg. 18 patients who reached the therapeutic goal (responders) continued in a double blind, cross-over study versus placebo, during which the supine BP fell on average 20/10 mmHg on the same dose of penbutolol, and 2/1 mmHg on placebo. Plasma concentrations (mean +/- SD) of free 0.10 +/- 0.07 microgram/ml) and total (2.02 +/- 1.39 microgram/ml) penbutolol did not differ between responders and nonresponders, and were not correlated with the fall in BP. Side effects were mild and mostly well tolerated. One patient developed dermatitis and another an elevation of liver enzymes.


Apr 1, 1977·Journal of Clinical Pharmacology·J J VallnerI L Honigberg
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May 1, 1990·Journal of Clinical Pharmacology·W H Frishman, S Covey
Jan 1, 1985·European Journal of Clinical Pharmacology·N BernardJ Sassard
Oct 1, 1996·Journal of Clinical Pharmacology·L M Prisant, G A Mensah
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Related Concepts

Diastolic Blood Pressure
Clinical Trials
Double-Blind Method
Hypertensive Disease

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