Pencil beam scanning versus passively scattered proton therapy for unresectable pancreatic cancer

Journal of Gastrointestinal Oncology
Michael ChuongRomaine C Nichols

Abstract

With an increasing number of proton centers capable of delivering pencil beam scanning (PBS), understanding the dosimetric differences in PBS compared to passively scattered proton therapy (PSPT) for pancreatic cancer is of interest. Optimized PBS plans were retrospectively generated for 11 patients with locally advanced pancreatic cancer previously treated with PSPT to 59.4 Gy on a prospective trial. The primary tumor was targeted without elective nodal coverage. The same treatment couch, target coverage and normal tissue dose objectives were used for all plans. A Wilcoxon t-test was performed to compare various dosimetric points between the two plans for each patient. All target volume coverage goals were met in all PBS and passive scattering (PS) plans, except for the planning target volume (PTV) coverage goal (V100% >95%) which was not met in one PS plan (range, 81.8-98.9%). PBS was associated with a lower median relative dose (102.4% vs. 103.8%) to 10% of the PTV (P=0.001). PBS plans had a lower median duodenal V59.4 Gy (37.4% vs. 40.4%; P=0.014), lower small bowel median V59.4 Gy (0.11% vs. 0.37%; P=0.012), lower stomach median V59.4 Gy (0.01% vs. 0.1%; P=0.023), and lower median dose to 0.1 cc of the spinal cord {35.0 vs...Continue Reading

Citations

Jan 7, 2021·Biomedicines·Eric J LehrerDaniel M Trifiletti
Nov 14, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Wei ZouLei Dong
Feb 16, 2021·International Journal of Radiation Oncology, Biology, Physics·Jiří KubešJozef Rosina
Aug 28, 2021·Journal of Personalized Medicine·Yoshitaka MatsumotoHideyuki Sakurai

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