PMID: 9186436Jun 1, 1997Paper

Penetrating keratoplasty in congenital hereditary endothelial dystrophy

Ophthalmology
A A al-Rajhi, M D Wagoner

Abstract

The purpose of the study is to determine the outcome of penetrating keratoplasty in congenital hereditary endothelial dystrophy. Records of 40 patients (13 males, 27 females) who underwent penetrating keratoplasty (56 eyes) were reviewed. The mean age at surgery was 11.8 years (range, 2 months-35 years). The mean follow-up was 37 months (range, 6-136 months). In 35 (62.5%) of 56 eyes that underwent primary penetrating keratoplasty, the grafts survived. Graft survival analysis showed the probability of obtaining a clear graft is 92% at 1 year, 72% at 2 years, and 56.5% at 5 years. Graft survival was statistically better in eyes where onset of the disease is delayed (P = 0.02), if the graft donor age is between 5 and 30 years versus older than 30 years (P = 0.02), and for patients who kept follow-up appointments versus those who were delinquent (P < 0.03). Visual acuity was 20/40 in 1.9%, 20/50 to 20/80 in 18.9%, 20/100 to 20/300 in 49%, and less than 20/400 in 30.2%. The main causes of graft failure were graft rejection (six eyes) and bacterial keratitis (four eyes). Penetrating keratoplasty in congenital hereditary endothelial dystrophy is moderately successful, and graft survival is better in cases of delayed onset compared wi...Continue Reading

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Citations

Apr 25, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jatin N AsharPravin K Vaddavalli
Jan 24, 2009·International Ophthalmology·Michael D WagonerUNKNOWN King Khaled Eye Specialist Hospital Cornea Transplant Study Group
Nov 8, 2001·International Ophthalmology Clinics·M A GrahamM R Dana
Aug 6, 2009·Cornea·Michael D WagonerUNKNOWN King Khaled Eye Specialist Hospital Cornea Transplant Study Group
Nov 3, 2011·Cornea·Roberto BellucciCarlo Bellucci
Jan 14, 2012·Cornea·Burak ÖzdemirYusuf Özertürk
May 9, 2014·Current Opinion in Ophthalmology·Hamed M Anwar, Alaa El-Danasoury
Mar 21, 2009·Survey of Ophthalmology·M VanathiTanuj Dada
Feb 20, 2007·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Ali Al-GhamdiMichael D Wagoner
Oct 1, 2010·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Abdulmajid Al-ShehahHind Alkatan
Dec 22, 2007·Seminars in Ophthalmology·Jessica Ciralsky, Kathryn Colby
Apr 5, 2017·Japanese Journal of Ophthalmology·Antonio Di ZazzoMichele Fortunato
May 10, 2017·The British Journal of Ophthalmology·Hamed AlArrayedhConor C Murphy
May 16, 2017·Current Opinion in Ophthalmology·Danielle TriefChristina R Prescott
Sep 19, 2020·Cornea·Nicolas Cesário PereiraAdriana Dos Santos Forseto

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