Penetration enhancer-containing vesicles (PEVs) as carriers for cutaneous delivery of minoxidil: in vitro evaluation of drug permeation by infrared spectroscopy

Pharmaceutical Development and Technology
Simona MuraC Sinico

Abstract

Recently, we carried out a research on new liposomal systems prepared by using in their composition a few penetration enhancers which differ for chemical structure and physicochemical properties. The penetration enhancer-containing vesicles (PEVs) were prepared by using soy lecithin and different amounts of three penetration enhancers, 2-(2-ethoxyethoxy) ethanol (Transcutol(®)), capryl-caproyl macrogol 8-glyceride (Labrasol(®)), and cineole.To study the influence of the PEVs on (trans)dermal delivery of minoxidil, in vitro diffusion experiments were performed through new born pig skin and the results were compared with that obtained applying the vesicular system without enhancer (control) after pretreatment of the skin with the various enhancers. In this study, Fourier transform infrared spectroscopy (FTIR), attenuated total reflectance FTIR (ATR-FTIR) and FTIR imaging were used to evaluate the effective penetration of minoxidil in the skin layers and to discover the influence of the enhancer on the drug topical delivery. These analytical studies allowed us to characterize the drug formulations and to evaluate the vesicle distribution into the skin. Recorded spectra confirmed that the vesicle formulations with penetration enhan...Continue Reading

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Citations

Apr 7, 2016·Pharmaceutical Development and Technology·R M BarbosaM H A Santana
Jul 3, 2015·Drug Development and Industrial Pharmacy·Maha Nasr, Sameh Abdel-Hamid
Feb 5, 2019·Current Drug Delivery·Heather A E BensonMichael S Roberts
Feb 25, 2015·Artificial Cells, Nanomedicine, and Biotechnology·Abdul AhadMohd Mujeeb
May 9, 2015·Artificial Cells, Nanomedicine, and Biotechnology·Abdul AhadMohd Mujeeb
Mar 17, 2018·Analytical and Bioanalytical Chemistry·David BonnelKim T Nielsen
Sep 22, 2017·Pharmaceutics·Christofori M R R NastitiMichael S Roberts
Nov 6, 2020·AAPS PharmSciTech·Ana Christina S OliveiraGuilherme M Gelfuso
Aug 7, 2019·Colloids and Surfaces. B, Biointerfaces·Vaishali Y Londhe, Bhavya Bhasin
Mar 4, 2021·Journal of Nanoscience and Nanotechnology·Chiara SinicoFrancesco Lai
May 8, 2020·International Journal of Pharmaceutics·Francesco LaiAnna Maria Fadda
Nov 10, 2021·Pharmaceutical Development and Technology·Ghada M El-Zaafarany, Maha Nasr

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