PMID: 6023264May 19, 1967Paper

Penetration of an organphosphorus compound into squid axon and its effects on metabolism and function

Science
F C Hoskin, P Rosenberg

Abstract

The tertiary analogute of phospholine, namely, (C(2)H(5)O)(2)P(O)SCH(2)CH(2)N(CH(3))(2), is a potent, irreversible inhibitor of cholinesterase which, when externally applied to the sqluid giant axon, readily penetrates in its inhibitory form into the axoplasm. However, even a 10(-2) molar solution of this compound does not block axonal conduction unless the axon is first treated with a low concentration of venom from the cottonmouth moccasin. The question of the activity of acetylcholinesterase in these axons is considered, and the possibility of subcellular permeability barriers for indivisual components of the excitable membrane is discussed.

References

Jul 14, 1966·Annals of the New York Academy of Sciences·D F ParsonsB Chance
May 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·F C HoskinM Brzin
Jul 14, 1966·Annals of the New York Academy of Sciences·D E Green, J F Perdue
Jul 14, 1966·Annals of the New York Academy of Sciences·D Nachmansohn
Nov 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·M Brzin
Jan 1, 1966·Advances in Comparative Physiology and Biochemistry·H Grundfest
Jun 1, 1965·Biochemical Pharmacology·M BrzinP Rosenberg
May 1, 1966·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·W W Schlaepfer, R M Torack
Mar 1, 1948·Journal of Neurophysiology·E A FELD, H GRUNDFEST
Jan 1, 1946·Journal of Neurophysiology·T H BULLOCKM A ROTHENBERG

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Citations

May 1, 1980·Bulletin of Environmental Contamination and Toxicology·D A FarquharsonR D Prusch
Oct 1, 1974·Bulletin of Environmental Contamination and Toxicology·R R Roales, A Perlmutter
Feb 1, 1975·Bulletin of Environmental Contamination and Toxicology·W D Dettbarn, F C Hoskin
Feb 3, 1999·Annals of the New York Academy of Sciences·K E LeJeuneA J Russell
Jun 1, 1972·Archives of Biochemistry and Biophysics·F C Hoskin, R J Long
Nov 1, 1971·Biochemical Pharmacology·L T Kremzner, P Rosenberg
Dec 11, 1970·Science·F C Hoskin, D Nachmansohn

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