PMID: 8956757Dec 1, 1996Paper

Penetration of antibiotics in diseased antral mucosa

Archives of Otolaryngology--head & Neck Surgery
V WestergrenU Forsum

Abstract

To investigate extracellular concentrations of antibiotics in inflammatory diseased sinus mucosa in critically ill patients and to find out whether there were any correlations between the concentrations of antibiotics in extracellular tissue and the presence of bacterial infection. Prospective case series. Sinoscopic findings were used as the criterion standard. The general and the neurosurgical intensive care units of a tertiary care hospital. Critically ill patients, nasotracheally intubated or tracheotomized, who received ventilator treatment (> 7 days) and antibiotic therapy. Bilateral sinoscopies were performed; antral secretions were collected for bacterial cultures; and serum and tissue samples were obtained for bioassay of antibiotic concentrations. The concentrations of all antibiotics found in extracellular fluid were lower than those found in serum samples. Measurable extracellular tissue concentrations of antibiotics were found in the antral mucosa, demonstrating that inflammatory maxillary sinus disease does not impede the antibiotic penetration of the mucosa or antibiotic activity in the extracellular tissue.

Citations

Apr 15, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·V Westergren

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Journal of the National Medical Association
A P SELTZER
British Medical Journal
M R SHERIDAN, T M BANHAM
Revista española de las enfermedades del aparato digestivo
F Serra FornesM Soto Ibáñez
Gastroenterology
G J Dockray, S Pauwels
© 2021 Meta ULC. All rights reserved