Penetration of cephazolin in human lumbar intervertebral disc

Spine
Rebecca WaltersR D Fraser

Abstract

Levels of the antibiotic cephazolin were measured in disc and blood from a consecutive series of patients undergoing lumbar spinal fusion. To determine if levels of cephazolin in the human disc reach the stated minimum inhibitory concentration against Staphylococcus aureus (1 mg/L) following intravenous administration, and to determine if there is a therapeutic relationship between serum concentration and disc concentration. Disc space infection is a potential complication of surgical procedures that violates the intervertebral disc. Bacteria, often from normal skin flora, can be introduced into the disc space causing inflammation with destruction of the adjacent vertebral endplate. Although there is substantial evidence from animal studies that prophylactic antibiotics reduce the incidence of discitis, similar evidence in human beings is not strong. A total of 30 patients, including 15 females and 15 males, with a mean age 42 years (range 21-63), received 1-g cephazolin (intravenous) during 1 or 2-level lumbar spinal fusion surgery. Venous blood was collected before administration of cephazolin and again at disc removal. Disc cephazolin concentrations were measured at the same time serum levels were measured for each patient. ...Continue Reading

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Mar 7, 2013·Surgical Infections·Dale W BratzlerUNKNOWN Society for Healthcare Epidemiology of America (SHEA)
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