PMID: 7547723May 1, 1995Paper

Penetration of ciprofloxacin into bone: a new bioabsorbable implant

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
J P OverbeckE Brug

Abstract

The implantation of antibiotic-containing cement beads became standard adjuvant local antibiotic therapy of chronic osteomyelitis. The new developed bioabsorbable drug carrier system of polyglycolic acid with the antibiotic Ciprofloxacin was tested in vitro and in vivo. The goal of this study was to determinate the penetration depth of Ciprofloxacin into bone cortex and marrow. Two monofil, PGA cylinders, 3.2 x 5 mm in size, containing 3 mg of Ciprofloxacin each, were implanted into the proximal part of both femora of 18 rabbits (New Zealand white). After sacrifice, the concentration of Ciprofloxacin in micrograms/g cortex and marrow was measured with high-performance liquid chromatography in relation to the distance from the test material at day 2, as well as at 1, 2, 3, 4, and 6 weeks postimplantation. For a distance up to 5 mm, marrow levels of the drug exceeded cortical levels at day 2 (5000 to 240 micrograms/g). At a distance of 5-10 mm, cortex levels were similar to marrow levels after 2 weeks and were higher than marrow levels at week 3. This observation could be made at a distance between 10 and 15 mm only after 2 days. Later, marrow concentrations again exceeded that in cortex. At a distance of more than 15 mm, antibio...Continue Reading

References

Jan 1, 1988·Reviews of Infectious Diseases·N Desplaces, J F Acar
Jun 1, 1986·Unfallchirurgie·K Klemm, M Börner

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Citations

Dec 5, 2006·Journal of Materials Science. Materials in Medicine·N AshammakhiP Törmälä
Dec 5, 2006·Journal of Materials Science. Materials in Medicine·Johanna TiainenNureddin Ashammakhi
Jul 6, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·C CastroE Sánchez
Dec 4, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·C CastroC Evora
Oct 22, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·M BaroC Evora
Aug 28, 2001·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·E SánchezC Evora
Jun 23, 2001·Plastic and Reconstructive Surgery·N AshammakhiT Waris
Jul 30, 2003·Clinical Pharmacokinetics·David StepenskyAmnon Hoffman
Aug 12, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yaron S BrinMeir Nyska
Mar 18, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shunmugaperumal TamilvananAnnick Ludwig
Dec 8, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Michal Y KraskoAbraham J Domb
Sep 27, 2005·Annales de chirurgie plastique et esthétique·D IeraN Ashmmakhi
Sep 17, 2013·Pharmaceutical Development and Technology·Doaa H MobarakSeham A Elkheshen
Aug 24, 1999·The Journal of Pharmacy and Pharmacology·Q YangG Owusu-Ababio
Oct 30, 2009·Journal of the Royal Society, Interface·Viviana Mouriño, Aldo R Boccaccini
Nov 13, 2003·Clinical Orthopaedics and Related Research·Catherine G AmbroseAntonios G Mikos
Mar 7, 2003·The Journal of Craniofacial Surgery·Nureddin AshammakhiTimo Waris
May 21, 2009·Journal of Biomaterials Science. Polymer Edition·Y S BrinM Nyska
Jun 1, 2006·Journal of Biomedical Materials Research. Part a·Jyri K KoortHannu T Aro
Jun 17, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Thomas KälickeStephan Arens
Mar 7, 2003·Journal of Orthopaedic Trauma·Shuji IsefukuA Hamish R W Simpson
Sep 14, 2012·The Cochrane Database of Systematic Reviews·Suetonia C PalmerGiovanni F M Strippoli
May 5, 2004·Clinical Orthopaedics and Related Research·Catherine G AmbroseAntonios G Mikos
Feb 27, 1999·Antimicrobial Agents and Chemotherapy·K KanellakopoulouH Giamarellou
Dec 17, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Karolina MulasMarcin Sobczak

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