PMID: 1012999Nov 1, 1976

Penetration of digoxin into cerebrospinal fluid

Postgraduate Medical Journal
G D SchottA M Hayler

Abstract

The concentration of digoxin in the cerebrospinal fluid (CSF) of ten patients receiving conventional oral doses of this cardiac glycoside has been measured by a radioimmunoassay technique. Digoxin was undetected in eight patients and barely detectable in two, suggesting the presence of a significant blood-CSF barrier for digoxin. The implication of these findings is discussed.

References

Oct 4, 1975·Lancet·G J NaylorM Peet
Jan 11, 1975·British Medical Journal
Jun 1, 1975·Journal of Clinical Pathology·D W Holt, J G Benstead
Nov 1, 1975·Circulation·R A Gillis
Dec 22, 1973·Lancet·A BertlerG Wettrell
Mar 2, 1974·Lancet·G D Schott, D W Holt
Dec 1, 1974·The Journal of Clinical Investigation·H GaranW J Powell
Jan 1, 1967·Annals of Internal Medicine·J E DohertyW J Flanigan

Citations

Apr 1, 1979·Clinical Cardiology·L StorsteinO Sjaastad
Jan 1, 1978·Journal of Clinical Pharmacology·J M GayesT W Smith
Nov 1, 1978·Journal of Neurochemistry·R Markstein, P L Herrling
Sep 1, 1977·Acta Pharmacologica Et Toxicologica·H AllonenG Wettrell
Sep 1, 2016·Neuro-oncology Practice·Benjamin Purow

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