Penetration of fleroxacin into breast milk and pharmacokinetics in lactating women.

Antimicrobial Agents and Chemotherapy
M DanH Zakut

Abstract

Fleroxacin was administered to seven lactating women as a single oral dose of 400 mg. Plasma, urine, and milk samples were collected for up to 48 h after administration. Drug concentrations were determined by a reversed-phase high-pressure liquid chromatography method and were used for the pharmacokinetic evaluation. At approximately 2 h after oral administration, a maximum concentration of 5.6 mg/liter was determined in plasma; the area under the plasma concentration-time curve (AUC) amounted to 70.3 mg.h/liter, and the elimination half-life in the postdistributive phase was 8 h. Total systemic clearance was 97.3 ml/min, and urinary excretion was 38% of the dose within 48 h. In addition, 8.6% of the N-demethyl metabolite and 4.4% of the N-oxide metabolite were recovered from urine. In comparison with previous results obtained with healthy male volunteers, the time to reach maximum concentrations in plasma was twice as long in the nursing women, and total clearance as well as urinary elimination were reduced by 25%. In breast milk, the mean maximum concentration was 3.5 mg/liter, which was reached 2.6 h after drug administration. The elimination half-life of fleroxacin in milk was identical to that in plasma, and the AUC reache...Continue Reading

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Citations

Jul 4, 2008·Clinical Pharmacology and Therapeutics·M Y Pepino, J A Mennella
Apr 17, 2007·Alcoholism, Clinical and Experimental Research·Marta Yanina PepinoJulie A Mennella
Oct 4, 2012·Journal of Veterinary Pharmacology and Therapeutics·O A ChiesaJ von Bredow
May 26, 2004·Pediatric Clinics of North America·Enrique M OstreaMaria Asuncion Silvestre
Feb 19, 2002·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·K G ChinC Mactal-Haaf
Jul 18, 2018·Basic & Clinical Pharmacology & Toxicology·Johannes J van WattumPeter G J Ter Horst
Jan 26, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Gracia MerinoJulio G Prieto

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