PMID: 2496363Mar 13, 1989Paper

Penetration of IgGs into the neuraxis of the neonatal rat

Neuroscience Letters
C E Hulsebosch, R H Fabian

Abstract

The permeability of the mammalian blood-brain barrier to macromolecules during prenatal and postnatal development is a controversial issue. We tested the possible access of xenogeneic antibodies to the neuraxis by examining neural tissue of neonatal rats 48 h after intraperitoneal injection of rabbit IgGs, using a modification of the peroxidase-antiperoxidase (PAP) technique. The results of the present study indicate diffuse immunoreactivity for rabbit IgGs in the parenchyma in all regions of the neuraxis in neonatal rats. This work suggests that immunoglobulins, both maternal and isogeneic, may affect the nervous system during prenatal and postnatal development.

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Citations

Oct 15, 1994·Journal of Neuroscience Research·R LoyR Perez-Polo
May 14, 1993·Brain Research·R H Fabian, C E Hulsebosch
Apr 1, 1991·Developmental Biology·M E BarishS S Raissdana
Apr 1, 1993·Neuropathology and Applied Neurobiology·T Moos, K Møllgård
Dec 31, 1997·Journal of Neuroimmunology·J R Tonra, L M Mendell
Sep 2, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Lada ZivkovićVladan Bajić
Jan 8, 2015·Frontiers in Neuroscience·Norman R SaundersHans-Christian Bauer
Jul 24, 2001·Journal of the American Podiatric Medical Association·B M LammH J Hillstrom
Jun 1, 1990·The Journal of Comparative Neurology·B A Urschel, C E Hulsebosch
Apr 21, 2016·Antibodies·Carolin HoffmannPilar Martinez-Martinez

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