Penetration of intravenously administered cefoxitin into the aqueous humor of inflamed human eyes

American Journal of Ophthalmology
J J KanskiR Vogel

Abstract

Intravenous injections of cefoxitin (2-g doses for adults and 40 mg/kg of body weight doses for children) were administered 90 minutes to two hours before surgery. All nine eyes had anterior segment inflammation. Samples of aqueous humor removed during surgery showed a mean cefoxitin concentration of 6.22 micrograms/ml, almost three times the concentration reported in uninflamed eyes. The greater penetration may have been the result of a breakdown in the blood-aqueous barrier. There were no complications.

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Citations

Dec 15, 1984·American Journal of Ophthalmology·D M Reifler
Apr 15, 1985·American Journal of Ophthalmology·A P JohnsonW J George
Feb 8, 2000·The Journal of Antimicrobial Chemotherapy·S F EggerG Grabner
Jan 1, 1983·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·C D Quentin, R Ansorg
Jul 1, 1987·European Journal of Pediatrics·R Lohrer, B H Belohradsky

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