PMID: 6105399Aug 2, 1980Paper

Penetration of mercury from ophthalmic preservatives into the human eye

Lancet
A F WinderM Ruben

Abstract

Single corneas of nine patients about to undergo full-thickness corneal keratoplasty were exposed to thiomersal by application of a hydrophilic gel contact lens preserved with this mercurial agent. These lenses were removed at operation 4 h later, and the lenses, corneal buttons, and samples of aqueous were taken for determination of total mercury by wet digestion and flameless atomic absorption. The contact lenses contained little residual mercury, but mercury was readily detected in the corneal buttons and in the samples of aqueous over the range of 1--60 ng/ml. Five control samples of aqueous obtained without exposure to mercurial preservatives contained less than 1 ng/ml mercury. Although specific effects on ocular function are not described, the use of these preservatives is associated with penetration of mercury into the aqueous in concentration similar to those reported with systemic poisoning by organic mercurials.

References

Nov 1, 1975·Journal of Pharmaceutical Sciences·R D Thompson, T J Hoffmann
Jan 1, 1970·The British Journal of Ophthalmology·J D Abrams, U Majzoub
Mar 1, 1965·The British Journal of Ophthalmology·J D ABRAMSM KLEIN

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Citations

Sep 8, 2011·Public Health Nutrition·Myriam FillionDonna Mergler
Aug 19, 2010·Environmental Health Perspectives·Mélanie LemireDonna Mergler
May 1, 1988·Medical Toxicology and Adverse Drug Experience·L K GolightlyB H Rumack
Jan 1, 1996·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·J P MorganJ W Kosman

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