Penetration of newer quinolones in the empyema fluid

The European Respiratory Journal
I E LiapakisDemosthenes Bouros

Abstract

The degree of penetration of newer quinolones into the pleural fluid has not been studied. The objective of the present study was to determine the degree to which moxifloxacin and levofloxacin penetrate into empyemic pleural fluid using a new rabbit model of empyema. An empyema was created via the intrapleural injection of turpentine (1 mL), followed 24 h later by instillation of 2 mL (1 x 10(10)) Escherichia coli bacteria (ATCC 35218) into the pleural space of New Zealand white rabbits. After an empyema was verified by thoracentesis and pleural fluid analysis, moxifloxacin and levofloxacin (25 mg.kg(-1) for both, i.v.) were administered. Antibiotic levels were determined in samples of pleural fluid and in blood collected serially over 12 h. Antibiotic levels were measured using HPLC. Each of the antibiotics penetrated well into the empyemic pleural fluid. Antibiotic penetration was the greatest for moxifloxacin (area under the curve (AUC) for pleural fluid/blood (AUCPF/AUCblood) ratio=1.37) followed by levofloxacin (ratio=1.13). The time to equilibration between the pleural fluid and blood antibiotic levels was more rapid for moxifloxacin (3.9 h) than for levofloxacin (4.4 h). With moxifloxacin, the peak pleural fluid concentr...Continue Reading

Citations

Jun 9, 2005·Respiration; International Review of Thoracic Diseases·I E LiapakisD E Bouros
May 21, 2010·Journal of Inflammation·Maria SaroglouDemosthenes Bouros
Oct 27, 2009·European Journal of Pharmacology·Maria SaroglouDemosthenes Bouros
Jul 15, 2015·The Lancet. Respiratory Medicine·John P CorcoranNajib M Rahman
Jun 29, 2014·The Journal of Surgical Research·Jeffrey H KozlowBenjamin Levi
Jun 1, 2006·The Annals of Pharmacotherapy·Kurt A WargoSteven A Higginbotham
May 22, 2018·Expert Review of Respiratory Medicine·Lucía FerreiroLuis Valdés
Dec 11, 2013·Antimicrobial Agents and Chemotherapy·Kalliopi ChatzikaIoannis Kioumis
Feb 2, 2019·Expert Review of Respiratory Medicine·Eihab O BedawiNajib M Rahman
Jan 1, 2010·Journal of Bronchology & Interventional Pulmonology·Kamran Mahmood, Charles Bower
Dec 14, 2016·Molecular Medicine Reports·Daniela CălinaEliza Gofita
Sep 20, 2017·Internal Medicine·Tatsuyoshi IkeueTakakazu Sugita
Dec 10, 2020·Pulmonary Therapy·Anand SundaralingamNajib M Rahman

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