Penetration of resveratrol into bovine aortic endothelial cells (BAEC): a possible passive diffusion

Comptes rendus biologies
Matthieu FrombaumDidier Borderie

Abstract

Several studies have demonstrated that, in a context of oxidative stress, resveratrol, a polyphenol found in wine, could act as a protective agent on endothelial cells by various mechanisms but without showing that it could penetrate inside the cell. The aim of this study was to detect for the first time resveratrol inside bovine endothelial aortic cells and to determine which kind of transport mechanism was involved. Intracellular and membrane concentrations of resveratrol have been measured by high performance liquid chromatography after incubation of several concentrations of resveratrol with endothelial cells for 24h. Concentrations of resveratrol in the culture media have been determined by UV spectrophotometry and experiments of transport mechanisms have been performed. Our results showed that, for the concentrations tested (1, 5, 10 and 50 μM), resveratrol was detected inside the cells and suggested that it was able to penetrate into the cells through a passive diffusion mechanism.

References

Jan 30, 2003·Clinical Biochemistry·David M GoldbergGeorge J Soleas
Feb 1, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Hui HeAndrew Keith Davey
Feb 9, 2007·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Allan LançonNorbert Latruffe
Jul 2, 2008·Chemistry and Physics of Lipids·Yara RhayemDominique Bonnefont-Rousselot
Jan 22, 2009·Analytica Chimica Acta·Laurent CamontDominique Bonnefont-Rousselot
Feb 6, 2009·Molecular Nutrition & Food Research·Luis AlmeidaPatrício Soares-da-Silva
Sep 23, 2009·Journal of Cardiovascular Pharmacology·Alberto A A Bertelli, Dipak K Das
Dec 17, 2009·American Journal of Physiology. Heart and Circulatory Physiology·M SulaimanM Gupta
Aug 24, 2010·BioFactors·Christoph A SchmittVerena M Dirsch
Jun 15, 2011·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Adela PinteaHorst A Diehl

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Citations

Nov 5, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ahmed AmriChristine Charrueau
Jun 5, 2019·International Journal of Molecular Sciences·Terézia Kisková, Monika Kassayová
Jan 23, 2020·Biomolecules·Terezia KiskovaMonika Kassayova

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