Abstract
Sparfloxacin (SPX), a novel fluoroquinolone with a broad spectrum of antibacterial activity, has been shown, in vitro, to be more effective against common pulmonary pathogens, particularly Streptococcus pneumoniae, Mycoplasma pneumoniae and some intracellular organisms, than ciprofloxacin (CPX). The objective of this open, comparative, randomized study in two parallel groups was to assess the serum concentrations and penetration of SPX and CPX into alveolar macrophages (AMs), epithelial lining fluid (ELF), and peripheral polymorphonuclear leucocytes (PMNs). Patients received either a single oral dose of SPX, 400 mg (16 patients), or CPX, 500 mg (15 patients), at various times before a routine diagnostic bronchoscopy was performed. Antibiotic concentrations were determined by using a microbiological assay. The median serum elimination half-lives were 17.3 h for SPX and 5.3 h for CPX. Peak levels (median+/-68% confidence range) of CPX were attained in AMs (7.6+/-1.7 mg x L(-1)) at 5 h after admission, and in both ELF (2.13+/-0.91 mg x L(-1)) and PMNs (9.1+/-6.2 mg x L(-1)) at 2.5 h after administration. SPX achieved comparable peak levels in PMNs (median+/-68% range, 9.4+/-1.1 mg x L(-1) at 5 h), but peak concentrations attained ...Continue Reading
Citations
Oct 17, 2012·The Journal of Antimicrobial Chemotherapy·Sandhya A MaratheDipshikha Chakravortty
Sep 12, 2007·Antimicrobial Agents and Chemotherapy·Sungmin Kiem, Jerome J Schentag
Jun 15, 2011·Antimicrobial Agents and Chemotherapy·Paschalina KontouIoannis Kioumis
Apr 25, 2012·Antimicrobial Agents and Chemotherapy·Hitoshi IshizukaHidetoshi Furuie
Dec 27, 2005·Antimicrobial Agents and Chemotherapy·Yuichi FukudaShigeru Kohno
Nov 15, 2001·Paediatric Drugs·J SinghA Arrieta
Sep 8, 2011·Clinical Pharmacokinetics·Keith A RodvoldLiz Yoo
Nov 9, 2005·American Journal of Veterinary Research·Harry W BootheDawn M Boothe
Jun 21, 2015·Expert Review of Anti-infective Therapy·Young R LeeRonald G Hall
Jul 3, 2007·Current Medical Research and Opinion·Gopal KrishnaZaiqi Wang
Jul 19, 2011·International Journal of Antimicrobial Agents·Coralie M ValletFrançoise Van Bambeke
May 4, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·B A Cunha
Oct 21, 1998·Infectious Disease Clinics of North America·D E Nix
Jan 25, 2002·Journal of Chemotherapy·B EkinciB Durupinar
Oct 9, 2001·Journal of Chemotherapy·M CazzolaF Rossi
Oct 4, 2015·Médecine et maladies infectieuses·C Chidiac, UNKNOWN SPILF working group
Jun 2, 2009·Biological & Pharmaceutical Bulletin·Makoto AokiMasahiro Hayashi
Jul 30, 2003·Memórias do Instituto Oswaldo Cruz·A Y Coban, B Durupinar
Jan 18, 2018·Antimicrobial Agents and Chemotherapy·Hidetoshi FuruieHisao Yoshida
Feb 4, 2014·Nature Reviews. Microbiology·Véronique Dartois
May 8, 2019·Antibiotics·Suzanne BongersFalco Hietbrink
Jun 24, 2017·Clinical Pharmacokinetics·Federico Pea
May 24, 2001·The Journal of Pharmacy and Pharmacology·M DorianM C Saux
Aug 15, 2018·Antimicrobial Agents and Chemotherapy·Vanessa E ReesCornelia B Landersdorfer
Dec 13, 2006·Treatments in Respiratory Medicine·George G ZhanelDaryl J Hoban
Jan 16, 2002·Drugs·George G ZhanelDaryl J Hoban
May 6, 2020·Antimicrobial Agents and Chemotherapy·Hajira BilalCornelia B Landersdorfer
Feb 26, 2021·Frontiers in Cellular and Infection Microbiology·Retsepile E MaphasaAdmire Dube
Sep 30, 2021·Microbiology Spectrum·Lloyd TannerLubbe Wiesner