Penetration of the Human Pulmonary Epithelium by Aspergillus fumigatus Hyphae

The Journal of Infectious Diseases
Julien FernandesMarina Pretolani

Abstract

The airway epithelium is the first barrier interacting with Aspergillus fumigatus conidia after their inhalation, suggesting that this structure functions as point of entry of this fungus to initiate pulmonary aspergillosis. To study epithelial entry by A fumigatus, primary human reconstituted pseudostratified epithelium cultured in air-liquid interface as well as bronchial epithelial cell monolayers were infected with conidia. Under these experimental conditions, we found that A fumigatus hyphae traversed the bronchial epithelium through a mechanism involving the recruitment of actin, which formed a tunnel that allows hyphae to enter the cells without disturbing their integrity. These findings describe a new mechanism by which A fumigatus hyphae penetrate the airway epithelial barrier and can infect its human host.

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Citations

Feb 12, 2019·Cellular Microbiology·Johannes WestmanGregory D Fairn
Nov 15, 2019·Clinical Microbiology Reviews·Jean-Paul Latgé, Georgios Chamilos
Jun 13, 2020·Frontiers in Immunology·Jeanne BigotChristophe Hennequin
Jan 17, 2021·The Journal of Allergy and Clinical Immunology·Maha Zohra LadjemiMarina Pretolani
Mar 19, 2021·PLoS Pathogens·Benoit BriardThirumala-Devi Kanneganti
May 4, 2020·Journal of Comparative Pathology·L Silva da CostaR A Casagrande
Oct 14, 2021·The New England Journal of Medicine·George R Thompson, Jo-Anne H Young

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Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

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