Penicilindoles A-C, Cytotoxic Indole Diterpenes from the Mangrove-Derived Fungus Eupenicillium sp. HJ002

Journal of Natural Products
Cai-Juan ZhengChang-Ri Han

Abstract

Three new indole diterpenes, penicilindoles A-C (1-3), were isolated from the mangrove-derived fungus Eupenicillium sp. HJ002. Their planar structures and absolute configurations were determined by interpretation of NMR spectroscopic data, HR-ESIMS, and X-ray diffraction analysis using Cu Kα radiation. The cytotoxic and antibacterial activities were evaluated in vitro; penicilindole A (1) showed cytotoxic activity against human A549 and HepG2 cell lines with IC50 values of 5.5 and 1.5 μM, respectively.

References

Sep 27, 2003·Journal of Natural Products·Chen LiDonald T Wicklow
Aug 28, 2010·Bioorganic & Medicinal Chemistry Letters·Ming-Feng QiaoQin-Zhao Xue
Jan 27, 2012·Journal of Natural Products·Cai-Juan ZhengChang-Yun Wang
Aug 20, 2014·Journal of Natural Products·Xue-Ming ZhouZhi-Gang Niu
Oct 14, 2016·Marine Drugs·Guo-Lei HuangGuang-Ying Chen
Mar 16, 2017·Natural Product Reports·John W BluntMichèle R Prinsep
Mar 28, 2017·Journal of Agricultural and Food Chemistry·Ting LiuWei-Cheng Liu

❮ Previous
Next ❯

Citations

Jul 4, 2019·The Journal of Antibiotics·Meng BaiGuang-Ying Chen
Jan 22, 2020·Natural Product Research·Rong-Qing MeiGuang-Ying Chen
Jan 10, 2020·Chemistry & Biodiversity·You-Ping LuoJing-Xian Han
Feb 7, 2020·Natural Product Reports·Anthony R CarrollMichèle R Prinsep
Jul 28, 2019·Marine Drugs·Meng BaiCai-Juan Zheng
Jun 20, 2020·Archiv der Pharmazie·Yang LiuGuishun Piao
Jun 24, 2020·Marine Drugs·Minghua JiangSenhua Chen
Sep 13, 2018·Marine Drugs·Elena AncheevaPeter Proksch
Oct 6, 2020·Natural Product Research·Meng BaiGuang-Ying Chen
Dec 16, 2020·Organic & Biomolecular Chemistry·Minghua JiangSenhua Chen
Jan 5, 2021·Russian Journal of Bioorganic Chemistry·A A BaranovaA P Tyurin
Jun 8, 2021·Natural Product Research·Boonyanoot ChaiyosangSomdej Kanokmedhakul
Apr 17, 2019·Journal of Natural Products·Meng BaiGuang-Ying Chen
Aug 20, 2021·The Journal of Antibiotics·Meng BaiYong-Hong Liu
Oct 9, 2021·Natural Product Reports·Senhua ChenZhigang She

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.