Penicillin Allergy Assessment in Pregnancy: Safety and Impact on Antibiotic Use.

The Journal of Allergy and Clinical Immunology. in Practice
Anna R WolfsonKimberly G Blumenthal

Abstract

Penicillin and other beta-lactam antibiotics are recommended for group B Streptococcus and cesarean section prophylaxis, but approximately 10% of pregnant patients report a penicillin allergy. To assess the safety and impact of penicillin allergy evaluation in pregnant patients. In this retrospective study of obstetrician-ordered Allergy/Immunology (AI) electronic consultations (e-consults) from September 20, 2017 through December 31, 2019, we reviewed the electronic health record for e-consult recommendation; patient demographic, obstetric, and allergy histories; and peripartum antibiotic utilization with indication. For patients whose electronic consultation recommended an in-person AI evaluation, testing outcomes were determined, and multivariable logistic regression models were used to compare antibiotic use between patients who did and did not receive an in-person AI evaluation. Of 389 obstetrician-ordered e-consults, 363 (93%) recommended an in-person AI evaluation; of these, 222 (61%) patients received an in-person AI evaluation. Of 220 (99%) patients skin tested, 209 (95%) had their penicillin allergy label safely removed. Compared with patients who did not receive an in-person AI evaluation despite it being recommended...Continue Reading

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Citations

Mar 10, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Melissa Iammatteo, Roland Solensky
Feb 20, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Allison RamseyKimberly G Blumenthal
Feb 6, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Bei Yuan ZhangChelsea Elwood
Aug 10, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Melissa IammatteoJean-Christoph Caubet

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