Penicillin and clindamycin therapy in recurrent tonsillitis. Effect of microbial flora

Archives of Otolaryngology--head & Neck Surgery
Perry A Foote, Itzhak Brook

Abstract

Fifty patients, scheduled for an elective tonsillectomy because of recurrent group A beta-hemolytic streptococcal tonsillitis, participated in a prospective randomized study that compared the efficacy of presurgical treatment with either phenoxymethyl penicillin or clindamycin hydrochloride in eradicating group A beta-hemolytic streptococci and beta-lactamase-producing bacteria (BLPB) from the tonsillar core. They were randomized into three groups as follows: 11 received penicillin, 22 received clindamycin, and 17 received no therapy. Group A beta-hemolytic streptococci were isolated from 8 (40%) of 17 untreated patients, 4 (36%) of 11 patients treated with penicillin, and none of 22 patients treated with clindamycin. Twenty-one BLPB were isolated from 16 (94%) of 17 untreated patients, 11 BLPB from 9 (82%) of 11 patients treated with penicillin, and 7 BLPB from 7 (32%) of 22 patients treated with clindamycin compared with penicillin or no therapy. Of the 22 patients treated with clindamycin, 10 were younger than 12 years of age. The BLPB were eradicated in nine patients (90%). However, BLPB were eradicated only in 6 (50%) of the 12 patients who were aged 13 years and older. These data illustrate the efficacy of clindamycin the...Continue Reading

Citations

Oct 28, 2005·Antimicrobial Agents and Chemotherapy·Itzhak Brook, Perry A Foote
Feb 11, 2011·Current Infectious Disease Reports·Itzhak Brook
Mar 17, 2009·International Journal of Pediatric Otorhinolaryngology·Itzhak Brook, Alan E Gober
Dec 6, 2005·Otolaryngologic Clinics of North America·Itzhak Brook
Aug 21, 2012·The British Journal of Dermatology·S L SigurdardottirA Johnston
Sep 12, 2006·International Journal of Pediatric Otorhinolaryngology·Itzhak Brook, Perry A Foote
Mar 2, 2012·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Olaf Zagólski, Jan Kulisiewicz
Nov 26, 2004·The Annals of Otology, Rhinology, and Laryngology·Itzhak Brook, Perry A Foote
Feb 1, 1993·The Annals of Otology, Rhinology, and Laryngology·I BrookW Jackson
Jul 19, 2005·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Itzhak Brook
Oct 11, 2005·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Debra M DonSally Davidson Ward
Sep 4, 1998·The Pediatric Infectious Disease Journal·I Brook
Apr 14, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Holger MunckTejs Ehlers Klug

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