Penicillin-binding protein 2 genes of non-beta-lactamase-producing, penicillin-resistant strains of Neisseria gonorrhoeae

Molecular Microbiology
C G DowsonB G Spratt

Abstract

Oligonucleotides that correspond to regions of the penicillin-binding protein 2 gene (penA) that differ between penicillin-sensitive and penicillin-resistant strains have been used as probes to classify the penA genes in a collection of penicillin-resistant gonococci isolated in Britain. 44/47 of those gonococcal strains that had minimal inhibitory concentrations of greater than or equal to 0.25 microgram benzylpenicillin per ml contained extensively altered penA genes which appeared to be very similar (or identical) to one or other of the two classes of altered penA genes that have been described previously. Since these two classes of altered penA genes are related, it appears that the great majority of the altered penA genes on non-beta-lactamase-producing penicillin-resistant gonococci have a clonal origin. The other three penicillin-resistant strains had altered penA genes that were different to those described previously. A crucial step in the development of the altered forms of PBP2 with decreased affinity for penicillin appears to have been the insertion of an extra codon within the transpeptidase domain of the penA gene. This insertion was found in the penA gene of all gonococci with minimal inhibitory concentrations of...Continue Reading

References

Oct 1, 1986·The Journal of Antimicrobial Chemotherapy·A E Jephcott
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D DiMaioT Maniatis
Aug 1, 1983·Journal of Medical Microbiology·C G Copley, S I Egglestone
Nov 1, 1980·Antimicrobial Agents and Chemotherapy·T J DoughertyA Tomasz

❮ Previous
Next ❯

Citations

Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B G SprattC G Dowson
Oct 1, 1993·Antimicrobial Agents and Chemotherapy·N H Georgopapadakou
Aug 15, 2001·Antimicrobial Agents and Chemotherapy·A MavroidiE Tzelepi
Feb 13, 2008·FEMS Microbiology Reviews·Eric SauvagePaulette Charlier
Sep 30, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ella TrembizkiDavid M Whiley
Jul 2, 2014·Clinical Microbiology Reviews·Magnus Unemo, William M Shafer
Aug 1, 1990·Molecular Microbiology·W M ShaferL W Huthwaite
Mar 17, 2009·Expert Opinion on Pharmacotherapy·Pennan M Barry, Jeffrey D Klausner
Jan 14, 2012·Annals of the New York Academy of Sciences·Magnus Unemo, William M Shafer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Bacterial Respiration

This feed focuses on cellular respiration in bacteria, known as bacterial respiration. Discover the latest research here.

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.