Penicillin-binding proteins of Streptomyces cacaoi, Streptomyces olivaceus, and Streptomyces clavuligerus.

Antimicrobial Agents and Chemotherapy
H Ogawara, S Horikawa

Abstract

Penicillin-binding proteins of three Streptomyces strains, S. cacaoi, S. olivaceus, and S. clavuligerus, were examined by gel electrophoresis and fluorography. In a beta-lactamase producer, S. cacaoi, at least five membrane-bound penicillin-binding proteins were detected, but in two beta-lactam producers, S. olivaceus and S. clavuligerus, fewer penicillin-binding proteins were detected. Mecillinam and methicillin bound selectively to some penicillin-binding proteins in S. cacaoi, whereas they did not bind at all to those in S. olivaceus and S. clavuligerus. Clavulanic acid bound to penicillin-binding proteins only at a very high concentration in S. cacoi. This compound did not bind to those of S. olivaceus and S. clavuligerus. Penicillin-binding proteins in culture supernatant and cytoplasm and minimum inhibitory concentrations of these strains against benzylpenicillin were also examined.

References

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Citations

Jul 1, 1982·Antimicrobial Agents and Chemotherapy·N H GeorgopapadakouD P Bonner
Oct 30, 2014·The Journal of Antibiotics·Hiroshi Ogawara
May 14, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hiroshi Ogawara
Jan 1, 1986·Annals of the New York Academy of Sciences·J T ThornthwaiteA Vazquez
Oct 13, 2020·Critical Reviews in Microbiology·Bikash Chandra Behera

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