PMID: 589449Nov 4, 1977

Penicillin effects on iontophoretic responses in Aplysia californica

Brain Research
T C Pellmar, W A Wilson

Abstract

The effect of penicillin on neurons of Aplysia californica was studied using drug concentrations which would be convulsant in mammalian nervous systems. Iontophoretic responses were elicited by the application of acetylcholine, dopamine, gamma-aminobutyric acid and serotonin. Low concentrations of penicillin (2 mM) consistently and reversibly reduced the chloride-dependent hyperpolarizing responses by approximately 70%, regardless of the transmitter required to evoke them. The short depolarizing responses which are sodium sensitive are slightly reduced by a much higher (10 mM) concentration. The extent of the reduction of the excitatory response varied with the transmitter. The slow sodium-dependent depolarizations and the slow potassium-dependent hyperpolarizations were unaffected by the concentrations of penicillin used. The possibility that the convulsant effect of penicillin is due to interference with membrane conductance to chloride is discussed.

Citations

Mar 1, 1987·Cellular and Molecular Neurobiology·N AkaikeD O Carpenter
Jun 1, 1988·Archives internationales de physiologie et de biochimie·V La GruttaG La Grutta
Dec 1, 1984·Cellular and Molecular Neurobiology·D S Weiss, J J Hablitz
May 6, 2019·Environmental Science and Pollution Research International·Adam BownikKinga Gałek
Apr 1, 1991·The American Journal of Physiology·T NakagawaN Akaike
Jan 1, 1985·Progress in Biophysics and Molecular Biology·W B Adams, J A Benson

Related Concepts

Acetylcholine Sulfate (1: 1)
Aplysia
Potentials, Event-Related
Iontophoresis
Resting Potentials
Neural Inhibition
Neurons
Van-Pen-G
Serotonin Antagonists
Sodium

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.