PMID: 374763Jun 8, 1979Paper

Penicillin levels in blood and CSF achieved by treatment of syphilis

JAMA : the Journal of the American Medical Association
E M DunlopE T Houang

Abstract

Treponemicidal levels of penicillin in the CSF were not obtained following intramuscular (IM) injections of 600,000 IU of penicillin G procaine along with 2% aluminum monostearate (PAM). Treponemicidal levels of penicillin in the CSF were achieved in 31 patients by probenecid, 500 mg/6 hr by mouth, with penicillin G, 500,000 IU by IM injection, and by probenecid every six hours by mouth and IM injections of penicillin G procaine once a day in two of three patients following injections of 600,000 IU, in four of five following 1.2 million IU, and in three (now all nine) following 2.4 million IU.

Citations

Apr 23, 2013·Clinical Pharmacokinetics·Antonello Di PaoloMario Del Tacca
Jun 1, 1990·Genitourinary Medicine·E M DunlopE T Houang
Dec 1, 1985·Genitourinary Medicine·R E MorrisonE C Tramont
Sep 5, 1981·British Medical Journal·E M DunlopE T Houang
Aug 1, 1981·The British Journal of Venereal Diseases·A LugerE Schonwald
Dec 1, 1980·The British Journal of Venereal Diseases·N PolnikornA Vejjajiva
Jun 6, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Khalil G GhanemKelly A Gebo
Feb 4, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Khalil G GhanemKelly A Gebo
Dec 1, 1983·Italian Journal of Neurological Sciences·L FaggiA Giannetti
Dec 1, 1983·International Journal of Dermatology·J W Dijkstra
Jul 16, 2010·CNS Neuroscience & Therapeutics·Khalil G Ghanem

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