Penicillin-resistant pneumococcus: practical implications

Jornal de pediatria
O C Mantese

Abstract

OBJECTIVE: To review epidemiological, laboratorial and clinical aspects of the penicillin-resistant pneumococcus, and to consider the impact of the rapidly increasing drug-resistance on the management of the main infections caused by these pathogens. METHODS: Bibliographic review covering the last ten years, using both Medline system and direct research. RESULTS AND CONCLUSIONS: The Streptococcus pneumoniae is an important agent in acute otitis media, pneumonia and meningitis in children. The clinical evaluation of the pneumococcal infections depends on the age and health condition of the patient, site and severity of the infection and the adequacy of the treatment. Penicillin was uniformly effective against pneumococcus until three decades ago, when the first reports of clinical resistance were published. Since then, there has been a rapidly increasing in the level and rates of resistance to penicillin, which parallels to others beta lactams and antimicrobials. This paper includes a suscint review of the genetic and phenotypic mechanisms of the resistance to penicillin, the available bacteriologic tests for determination of in vitro susceptibility to antimicrobials and finally the importance of the pneumococcus in acute otitis...Continue Reading

Related Concepts

beta-Lactams
Vaccines, Conjugate
Etiology
Refractory Cancer
Pneumococcal Infections
Epidemiology
Pneumonia
Penicillins
Otitis Media
Microbicides

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Meningitis

Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Meningitis (ASM)

Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.