Penicillium marneffei infection in HIV

Current Opinion in Infectious Diseases
Andrew P UstianowskiJeremy N Day

Abstract

Since the start of the HIV pandemic, systemic infection with Penicillium marneffei has developed from a very rare diagnosis to the third most common opportunistic infection in HIV co-infected patients in South East Asia. HIV patients who have travelled to or lived in Asia may present with this infection in nonendemic countries, and it has therefore become important for all those working in the field of HIV to recognize, understand and treat this emerging disease. The clinical features, diagnosis and treatment of this infection are reviewed. Recent data exploring antigen-based serodiagnostics, the role of newer antifungals such as voriconazole, and the possibility of discontinuation of secondary prophylaxis after immune restoration from highly active antiretrovirals are discussed. Large series from endemic areas and case reports from nonendemic regions have been published and provide insights into clinical features and presentation. Novel diagnostics are evolving, with galactomannan and other assays looking promising. Present therapy is largely based on noncontrolled studies, and further research into optimal therapy and the potential to discontinue secondary itraconazole prophylaxis is required.

References

Oct 1, 1986·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·Z L DengL Ajello
Aug 1, 1973·American Journal of Clinical Pathology·A F DiSalvoL Ajello
Aug 1, 1995·Journal of Clinical Microbiology·L KaufmanB L Swisher
Jul 9, 1994·Lancet·K SupparatpinyoT Sirisanthana
Dec 1, 1993·The Pediatric Infectious Disease Journal·V Sirisanthana, T Sirisanthana
May 1, 1993·Infection·Y LermanY L Danon
Oct 1, 1993·Infection and Immunity·O G BacaA S Aragon
Nov 1, 1995·The Pediatric Infectious Disease Journal·V Sirisanthana, T Sirisanthana
May 3, 1996·The Journal of Biological Chemistry·T J ReillyM S Kuhlenschmidt
Mar 1, 1996·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·S ChariyalertsakN Vanittanakom
Jul 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·T A Duong
Jun 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S ChariyalertsakK E Nelson
Feb 10, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C C HungK T Luh
Feb 14, 1998·The Journal of Antimicrobial Chemotherapy·N VenkataprasadJ J Ellner
May 23, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·T SirisanthanaK E Nelson
Nov 30, 1998·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·T Sirisanthana, K Supparatpinyo
Mar 4, 2000·International Journal of STD & AIDS·F J VilarN P Jones
Jul 18, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·Y LoT Hoppe
Apr 20, 2001·Mycopathologia·P ImwidthayaJ Jearanaisilavong
Dec 12, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Suwat ChariyalertsakKenrad E Nelson
Sep 10, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Benjaporn ChaiwunPaul Thorner
Nov 6, 2004·Journal of Clinical Microbiology·Matthew C FisherNongnuch Vanittanakom
Nov 6, 2004·Journal of Clinical Microbiology·Harish GugnaniPratap Singh Yadav
Oct 26, 2005·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Piroon Mootsikapun, Sukanya Srikulbutr
Jan 19, 2006·Clinical Microbiology Reviews·Nongnuch VanittanakomThira Sirisanthana
Mar 10, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·H-Y SunS-C Chang

❮ Previous
Next ❯

Citations

Aug 9, 2008·The Journal of Biological Chemistry·Anthony J O'DonoghueMaria G Tuohy
Nov 9, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pamela P W LeeYu-Lung Lau
Jan 13, 2010·Clinical Microbiology Reviews·Geraldine Butler
Aug 7, 2010·MBio·Monica A Garcia-Solache, Arturo Casadevall
Aug 2, 2014·AIDS Research and Human Retroviruses·Takeshi NishijimaShinichi Oka
Oct 17, 2012·Clinics in Dermatology·Ricardo GalimbertiFlorencia Rodriguez-Chiappetta
Feb 18, 2014·Trends in Microbiology·Darius Armstrong-JamesGordon D Brown
Apr 14, 2016·Future Microbiology·Harshini WeerasingheAlex Andrianopoulos
Oct 30, 2012·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Donghua LiuJimin Chen
Nov 21, 2017·F1000Research·Anna SkiadaMaria Drogari-Apiranthitou
Jul 19, 2017·The American Journal of Tropical Medicine and Hygiene·Jun ChenHongzhou Lu
Sep 9, 2017·Future Science OA·Monsicha PongpomNongnuch Vanittanakom
Sep 18, 2012·Mycopathologia·Yongxuan HuLiyan Xi
Sep 3, 2010·Journal of Orthopaedic Surgery·Edmund Leung-kai Yau, Ka-Kin Li
Jan 14, 2011·Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases·Yoshihiko OgawaTakuma Shirasaka
Jan 7, 2015·Indian Journal of Medical Microbiology·Feng YeRongchang Chen
Jun 28, 2021·Current Opinion in Immunology·Han-Po ShihCheng-Lung Ku

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.