Penile and Scrotal Swelling: An Underrecognized Presentation of Crohn's Disease

Pediatric Dermatology
Benjamin J BarrickDawn M R Davis

Abstract

Penile and scrotal swelling can occur as an extraintestinal manifestation of Crohn's disease (CD) and is thought to be an uncommon form of metastatic CD (MCD). Because of the rarity of this manifestation, much is unknown concerning the presentation, treatment, and response to therapy in children with genital MCD. Boys ages 1 to 17 years presenting with genital edema and a confirmed diagnosis or strong suspicion of CD who were evaluated at the Mayo Clinic between 1996 and 2014 were included for review. We sought to characterize the clinical and pathologic features of genital MCD and response to treatment in our cohort of patients. Eight patients with genital MCD were identified from our institution (mean age 11.4 yrs, range 7-16 yrs). Seven (88%) patients experienced cutaneous symptoms before a formal diagnosis of CD was made, and two of the seven had no adverse gastrointestinal symptoms at that time. Patients were prescribed an average of 3.4 medications (topical and systemic) for management of their gastrointestinal CD and MCD. Penile and scrotal swelling can occur as an extraintestinal manifestation of CD and is thought to be an uncommon form of MCD. In boys, genital swelling typically precedes intestinal CD. Treatment of the...Continue Reading

References

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Citations

Jul 22, 2017·Pediatric Dermatology·Aizuri MuradPatricia Lenane
Nov 29, 2017·Clinical Pediatrics·Megan S EvansDean S Morrell
Jun 29, 2018·Pediatric Dermatology·Samantha L SchneiderTor Shwayder
Dec 19, 2019·JAMA Dermatology·Reese L Imhof, Megha M Tollefson
Sep 24, 2020·Pediatric Dermatology·Daniel MazzoniLaura Wheller
Dec 7, 2018·Pediatrics in Review·Maureen RiegertLisa M Arkin
Nov 22, 2017·Pediatric Dermatology·Tashmeeta AhadCaroline Owen
Mar 16, 2017·American Journal of Clinical Dermatology·Michelle XuAmor Khachemoune

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