Penile angioedema developing after 3 years of ACEI therapy

The Journal of Emergency Medicine
Daniel G MillerTheodore S Toerne

Abstract

Angiotensin-converting enzyme inhibitor-related angioedema (ACEI-RA) is a well-described condition, yet isolated genital ACEI-RA is a little-known entity. A case of isolated genital angioedema is presented with photographic documentation. Possible complications and therapeutic options are discussed. A 71-year-old man presented with painless, nonpruritic genital swelling of 4 h duration. Medical history included peptic ulcer disease, hypertension, and benign prostatic hypertrophy. His medications included pantoprazole, hydrochlorothiazide, and lisinopril, which he had been taking for 3 years without any recent change in dosing. He was otherwise asymptomatic and previously had been in good health generally. The physical examination was positive only for diffuse, soft, nonpitting edema isolated to the scrotum and uncircumcised penis. The foreskin was only partially retractable. Urinalysis was normal. All symptoms resolved without complications within 48 h of discontinuing lisinopril and had not recurred at follow-up 4 months later. All cases of ACEI-RA isolated to the genitals that have been reported in the literature resolved without complications. ACEI-RA can present as isolated swelling of the genitals and is a potential cause ...Continue Reading

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Citations

Mar 16, 2017·Critical Care Medicine·Daniel LoVerdeGuha Krishnaswamy
Jun 8, 2013·Current Opinion in Allergy and Clinical Immunology·Paloma CampoCristobalina Mayorga
Mar 4, 2014·Biotechnology, Biotechnological Equipment·Shujing ShengXia Rong
Feb 7, 2018·Indian Journal of Dermatology, Venereology and Leprology·P S S Ranugha, Jayadev B Betkerur
Oct 18, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Ilaria MormileAngelica Petraroli

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