Penile pseudomyogenic hemangioendothelioma/epithelioid sarcoma-like hemangioendothelioma with a novel pattern of SERPINE1-FOSB fusion detected by RT-PCR--report of a case

Pathology, Research and Practice
Yoshi-Hiro IdeSeiichi Hirota

Abstract

We experienced a rare case of penile mesenchymal tumor in a 43-year-old Japanese man. At least three nodules were observed around the penis. The tumors were composed of spindle- to oval-shaped atypical cells with and without prominent nucleoli. These cells were like myogenic cells, but negative for myogenic markers. They were positive for endothelial markers, such as ERG, Fli1 and CD31. They were also positive for nuclear and cytoplasmic FOSB which are not expressed in epithelioid hemangioendothelioma or epithelioid sarcoma. These pathological and immunohistochemical findings strongly suggested pseudomyogenic hemangioendothelioma/epithelioid sarcoma-like hemangioendothelioma (PHE/ES-HE). Since a recent report directly proved that two cases of PHE/ES-HE have SERPINE1-FOSB fusion gene by reverse transcription-polymerase chain reaction (RT-PCR), we examined whether the fusion gene is present or not in the present case by RT-PCR using fresh frozen surgical material. Sequencing of the PCR product revealed that this case has SERPINE1-FOSB fusion. The fusion pattern of our case was different from those of two previously reported cases. In our case, 86 nucleotides of SERPINE1 intron 1 were inserted between SERPINE1 exon 1 and the middl...Continue Reading

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Citations

Dec 24, 2016·The American Journal of Surgical Pathology·Yin P HungJason L Hornick
Sep 17, 2017·Journal of Clinical Pathology·Elina ShustefPhyu P Aung
Feb 7, 2018·The American Journal of Dermatopathology·Emily RaftopoulosWalter Rush
Sep 27, 2018·The American Journal of Surgical Pathology·Narasimhan P AgaramCristina R Antonescu
Dec 24, 2018·Archives of Pathology & Laboratory Medicine·Ayah Al-Qaderi, Ahmad T Mansour
Nov 9, 2019·Virchows Archiv : an International Journal of Pathology·Khin Thway, Andrew L Folpe
Jan 26, 2020·Virchows Archiv : an International Journal of Pathology·Yuefang SunJian Wang
Feb 13, 2016·The American Journal of Surgical Pathology·Alero InyangAndrew E Rosenberg

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