Pentachlorophenol and cancer risk: focusing the lens on specific chlorophenols and contaminants.

Environmental Health Perspectives
Glinda S Cooper, Samantha Jones

Abstract

Pentachlorophenol, a fungicide widely used as a wood preservative, was classified in 1999 by the International Agency for Research on Cancer as a possible human carcinogen. We reviewed currently available data to determine the extent to which recent studies assist in distinguishing the effect of pentachlorophenol from that of its contaminants (e.g., dioxins and other chlorophenols). We performed a systematic review of published studies pertaining to cancer risk in relation to pentachlorophenol exposure, focusing on results pertaining specifically to all cancer sites and specific hematopoietic cancers, and data pertaining to risks associated with other types of chlorophenols, dioxins, or furans. The pentachlorophenol studies presented considerable evidence pertaining to hematopoietic cancers, with strong associations seen in multiple studies, in different locations, and using different designs. There is little evidence of an association between these cancers and chlorophenols that contain fewer than four chlorines. The extension of a large cohort study of sawmill workers, with follow-up to 1995, provided information about risks of relatively rare cancers (e.g., non-Hodgkin lymphoma, multiple myeloma), using a validated exposure ...Continue Reading

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