PMID: 3497672Jul 1, 1987

Pentagastrin as a stimulator of immunogenesis

Biulleten' eksperimental'noĭ biologii i meditsiny
I V Molchanova, G A Belokrylov

Abstract

It has been shown that subcutaneous injection of pentagastrin to mice in doses 0.01-5 micrograms per animal during 10 days resulted in a considerable stimulation of the immune response to sheep red blood cells (SRBC). Pentagastrin in doses of 5 and 1 micrograms per animal was demonstrated to have the highest immunostimulating effect. These doses increased the production of IGM-antibody-forming cells 2.2-2.7-fold and produced a twofold elevation of the antibody titer. Pentagastrin did not influence the immune response to thymus independent Vi-antigen. The in vitro treatment of mouse bone marrow cells with pentagastrin (0.1 or 0.01 microgram/ml) increased the number of Thy-1 positive cells from 0 to 16-17%. Pentagastrin at a dose of 0.001 microgram/ml was not effective.

References

Nov 1, 1989·Digestive Diseases and Sciences·G F JinC W Houston
Jan 1, 1990·International Journal of Immunopharmacology·G A BelokrylovE I Sorochinskaya

Citations

Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R S Basch, G Goldstein
Apr 26, 1963·Science·N K Jerne, A A Nordin

Related Concepts

Mice, Inbred CBA
Immune Response
T-Lymphocyte
Variolation
Colony-Forming Units, Hematopoietic
PRKCDBP gene
Immunologic Adjuvants
Subcutaneous Injections
Neoplasm of Uncertain or Unknown Behavior of Thymus
Red blood cells, blood product

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