PMID: 3756499Aug 27, 1986Paper

Pentobarbital and halothane hyperpolarize cat alpha-motoneurons

Brain Research
J F Whitney, L L Glenn

Abstract

The effect of anesthetics on the membrane potential of spinal alpha-motoneurons was studied in awake-intact cats that were sequentially anesthetized with either halothane or pentobarbital. Pentobarbital (35 mg/kg) and halothane (5%) both induced a 5 mV hyperpolarization and a reduction in spontaneous synaptic activity of motoneurons. We suggest that a reduction in the urinary EPSP frequencies contributes to the hyperpolarization and the membrane potential criterion of acceptable impalements of motoneurons in awake-intact preparations should be 5 mV more depolarized than that in anesthetized preparations.

References

Jan 1, 1978·General Pharmacology·C D Richards
Jan 1, 1967·Anesthesiology·G Somjen
Jun 2, 1980·Brain Research·R A Nicoll, J M Wojtowicz

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Citations

Jan 1, 1989·Neuroscience and Behavioral Physiology·E S Brazhnik, O S Vinogradova
Apr 1, 1989·Pharmacology, Biochemistry, and Behavior·M M McCarthyB R Komisaruk
Oct 20, 2000·Brain Research. Molecular Brain Research·C H KindlerA T Gray
Feb 9, 2002·Brain Research. Molecular Brain Research·Anja GabrielChristoph H Kindler
Jun 25, 1990·Brain Research·S K SalzmanG M Freeman

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