Pentobarbital inhibits L-DOPA-induced dopamine increases in the rat striatum: An in vivo microdialysis study

Brain Research Bulletin
Yushi U AdachiShigehito Sato

Abstract

Pentobarbital is reported to inhibit ketamine-induced dopamine (DA) release in the rat nucleus accumbens. The accumbens is a part of the limbic dopaminergic system in the brain, and the dopaminergic neural activity of other components may also be sensitive to pentobarbital. We investigated the effect of pentobarbital administration on DA release in the striatum known as DA-rich basal ganglia, and the interaction between pentobarbital and L-DOPA, using in vivo microdialysis techniques. Male SD rats were implanted microdialysis probe into the right striatum. The probe was perfused with modified Ringer's solution and dialysate was directly injected to an HPLC. Every group of rats was consisted of six to seven animals. In the first experiment, rats were given saline, 25 and 50 mg kg(-1) pentobarbital. The second, each rat was given a local administration of 2 and 5 microg ml(-1) of L-DOPA with perfusate. Finally, other sets of rats were given 5 microg ml(-1) of L-DOPA and 25, 50, or 100 mg kg(-1) pentobarbital. Pentobarbital anaesthesia decreased the extracellular concentration of DA, and local administration of L-DOPA significantly increased DA concentration. Pretreatment with pentobarbital diminished the L-DOPA-induced DA increas...Continue Reading

References

Jan 1, 1995·Anesthesiology·S Muravchick, D S Smith
Oct 26, 1999·Trends in Neurosciences·R Spanagel, F Weiss
Dec 13, 2001·Neurochemistry International·Yushi U AdachiGabriella Zsilla
Sep 16, 2003·Neuron·William Dauer, Serge Przedborski
Oct 27, 2004·Cell and Tissue Research·Saleem M NicolaGregory O Hjelmstad
Jan 29, 2005·Journal of Neurology·Thomas MüllerJohannes Schwarz

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Citations

Mar 19, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Toru KawadaMasaru Sugimachi
Mar 28, 2008·Journal of Neurochemistry·Laura E BiancoJohn L Beard
Sep 3, 2011·Journal of Neurochemistry·Christian P MüllerMaria A De Souza Silva

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