PMID: 34691Mar 1, 1979

Pentobarbitone and skeletal muscle contractions: on the interaction with the effect elicited by the beta-adrenoceptor agonist, terbutaline

The Journal of Pharmacy and Pharmacology
E Holmberg, B Waldeck

Abstract

The soleus, a slow-contracting muscle, and the extensor digitorum longus (EDL), a fast-contracting muscle from guinea-pig were prepared for isometric recording in vitro. Subtetanic contractions were evoked by transmural field-stimulation. Pentobarbitone increased the force of contraction in both muscles. In the soleus it shifted the stimulation frequency-response curve to the left. Terbutaline caused a decrease in the force of subtetanic contractions of the soleus, an effect which was dependent on the stimulation frequency. In the presence of pentobarbitone, the stimulation frequency had to be lowered by about 2 HZ in order to maintain the optimum response to terbutaline. The EDL responded to terbutaline with an increased force of contraction. In this case the stimulation frequency was less critical and the effects were the same in the presence and in the absence of pentobarbitone. Experiments with alpha-chloralose yielded results similar to those obtained with pentobarbitone.

References

Sep 1, 1977·The Journal of Pharmacy and Pharmacology·B Waldeck
Dec 1, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·E Holmberg, B Waldeck
Sep 15, 1969·Experientia·J BergmanK Wetterlin
Feb 1, 1973·Canadian Journal of Physiology and Pharmacology·J G FoulksH Washio
Sep 15, 1969·Experientia·R O Studer
Nov 5, 1956·Acta Physiologica Scandinavica·S THESLEFF
Nov 1, 1964·The Journal of General Physiology·M E CARSTEN, W F MOMMAERTS

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