Pentose cycle pathway in normal and tumoral islet cells

FEBS Letters
M H GiroixW J Malaisse

Abstract

Relative to protein content, the activity of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase and the rate of glucose metabolism by the pentose cycle pathway in tumoral insulin-producing cells were similar to or higher than those found in normal rat islets. Hence, the decreased secretory response of tumoral cells to glucose is apparently not attributable to any major anomaly in glucose handling by the hexose monophosphate pathway.

References

Aug 1, 1985·Diabetologia·W J Malaisse, A Sener
Feb 1, 1972·The Biochemical Journal·S J AshcroftP J Randle
Sep 1, 1981·Diabetologia·A M SopwithC N Hales
Feb 15, 1983·The Biochemical Journal·G A PrazA E Renold

Citations

Mar 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R WillemW J Malaisse
Jan 1, 1991·The International Journal of Biochemistry·W J Malaisse, H Bodur
Jan 1, 1986·Comparative Biochemistry and Physiology. A, Comparative Physiology·M H GiroixW J Malaisse
Dec 24, 2002·Biochimica Et Biophysica Acta·M J MacDonald
Dec 30, 1987·European Journal of Biochemistry·A SenerW J Malaisse
May 3, 2012·American Journal of Physiology. Endocrinology and Metabolism·Joshua P GrayEmma A Heart
Aug 1, 1988·Biochemical Medicine and Metabolic Biology·W J MalaisseA Sener
Jul 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·M J MacDonald

Related Concepts

Metazoa
Anhydrous Dextrose
Glucosephosphate Dehydrogenase
Insulinoma
Islets of Langerhans
Islet Cell Adenoma
Oxidation-Reduction
Malignant Neoplasm of Pancreas
Pentose Phosphate Pathway
Phosphogluconate Dehydrogenase

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