Pentosidine, advanced glycation end product, in acute ischaemic stroke patients with and without atrial rhythm disturbances

Neurologia i neurochirurgia polska
Marta Leńska-MieciekUrszula Fiszer

Abstract

Atrial fibrillation (AF) and atherosclerotic disease are independent risk factors for acute ischaemic stroke (AIS). The optimal biological marker which could allow differentiation between AF and non-AF AIS patients is still not available. Aim of the present study was to investigate the role of pentosidine as a potential biological marker for AF in an AIS patient group. Sixty-three acute ischaemic hemispheric stroke patients were recruited and divided into two groups according to the presumed underlying mechanism: with or without atrial rhythm disorders. Ten healthy volunteers were a reference group for serum level of pentosidine. Carotid artery ultrasound was performed, and common carotid artery stiffness and intima-media thickness were measured. Serum levels of pentosidine and selected routine biochemical risk factors for atherosclerosis (cholesterol and its lipoprotein fractions, homocysteine) were examined. A higher serum level of pentosidine was observed in patients without atrial fibrillation (1,509 ± 485.13pmol/ml); a statistically significant difference was observed compared to the reference group (1,041.52 ± 411.17pmol/ml; p = 0.01), but not the AF patients (1,438.19 ± 495.97pmol/ml; p = 0.59). No significant difference...Continue Reading

Citations

Jun 22, 2021·Geriatrics & Gerontology International·Tomohiko UranoMitsuru Saito

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