PMID: 8599282Jan 1, 1995Paper

Pentoxifylline and oxygen consumption in severe sepsis--a preliminary report

Acta Anaesthesiologica Scandinavica. Supplementum
J A Castañon-GonzalezR Miranda-Ruiz

Abstract

To demonstrate that pentoxifylline (PTX) and not placebo improves oxygen consumption (VO2) in critically ill patients with severe sepsis. Multidisciplinary intensive care unit in a university affiliated hospital. A randomized, double blinded clinical trial comparing 300 mg of PTX administered in a 120 min iv infusion with an identically looking placebo. 13 patients (9 men and 4 women) average age 39 (24-62) years old received PTX, and 12 patients (5 men and 7 women) average age 38 (21-83) years old received placebo. All satisfied ACCP/SCCM criteria for severe sepsis. Patients fulfilling criteria for severe sepsis was identified on admission, cardiac output, DO2 and VO2 were measured by thermodilution and standard oximetric technics after adequate volume replacement at baseline, 60 and 120 during infusion. F-test of analysis of variance was used to test hypothesis about differences of DO2 and VO2 by group, by time and for the interaction terms, a "p" value < 0.05 was considered significant. Evaluation of baseline measurements of both groups revealed no significant difference in any haemodynamic function or oxygen transport variables. The average VO2 difference (0-120 min) between groups was 21 mL/min.m2 and it was higher in the ...Continue Reading

References

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Citations

Jan 1, 1997·Critical Care Medicine·J A Castanón-GonzálezR Miranda-Ruíz
Mar 13, 2002·Critical Care Medicine·Jürgen GrafWilliam J Sibbald
Jan 5, 2013·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Matthew B DufekDhiren R Thakker
Aug 15, 2003·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·A KerssenG H A Visser

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